Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors VI. A Series of New Derivatives Containing N,S- and N,SO_2-Spiro Acetal Scaffolds
スポンサーリンク
概要
- 論文の詳細を見る
In the course of development of factor Xa (FXa) inhibitors, we have found unique compounds containing an N,O- and an N,N-spiro acetal structure. It appeared that the difference in overall conformation due to the N,X-spiro acetal structure might be important for FXa inhibitory activity. Therefore, other N,X-spiro acetal structures, an N,S- and an N,SO_2-spiro acetal, were developed as analogues of the N,X-spiro acetal structure. Compound 7b (N,S-spiro acetal structure) was found to have the strongest activity in these series of N,X-spiro acetal compounds, which had ever been synthesized.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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Mizuno Masashi
Division Of Science Of Biological Resources The Graduate School Of Science And Technology
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Mizuno Masashi
Division Of Life Science Graduate School Of Science And Technology Kobe University
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Mizuno Masashi
Graduate School Of Science And Technology Kobe University
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Mizuno Masashi
Nagano Japan Radio Co. Ltd. Currently With Kyushu Institute Of Technology
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Mizuno M
Kobe Univ. Kobe Jpn
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Ohashi M
Chemistry Laboratory Research Center Mochida Pharmaceutical Co. Ltd.
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YAMAMOTO Ichiro
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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SAITOH Fumihiko
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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NISHIDA Hidemitsu
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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MUKAIHIRA Takafumi
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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KOSUGA Naoto
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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OHKOUCHI Munetaka
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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MATSUSUE Tomokazu
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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SHIROMIZU Ikuya
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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HOSAKA Yoshitaka
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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MATSUMOTO Miwa
Pharmaceutical Research Center, Mochida Pharmaceutical Co., Ltd.
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Mizuno M
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Morimoto M
Graduate School Of Science And Technology Kobe University
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Kosuga Naoto
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Saitoh F
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Shiromizu Ikuya
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Hosaka Y
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Matsusue Tomokazu
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Nishida H
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Ohkouchi Munetaka
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Mukaihira Takafumi
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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Yamamoto Ichiro
Pharmaceutical Research Center Mochida Pharmaceutical Co. Ltd.
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