Transepithelial Transport of p-Coumaric Acid and Gallic Acid in Caco-2 Cell Monolayers(Food & Nutrition Sience)
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概要
- 論文の詳細を見る
The transepithelial transport of such common dietary phenolic acids as p-coumaric acid (CA) and gallic acid (GA) across Caco-2 cell monolayers was examined. CA transport was dependent on pH, and in a vectorial manner in the apical-basolateral direction. The permeation was concentration-dependent and saturable, the Michaelis constant and maximum velocity being 17.5 mM and 82.7 nmol min^<-1> (mg of protein)^<-1>, respectively. Benzoic acid and acetic acid inhibited the permeation of CA. These results indicate that the transepithelial transport of CA was via the monocarboxylic acid transporter (MCT). On the other hand, the permeation of GA was not in a polarized manner, was independent of pH and linearly increased with increasing concentration of GA. The transport rate of GA was about 100 times lower than that of CA, suggesting the transepithelial transport of GA to be via the paracellular pathway. Dietary phenolic acids thus showed diversified characteristics in their intestinal absorption.
- 社団法人日本農芸化学会の論文
- 2003-11-23
著者
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SHIMIZU Makoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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KOBAYASHI Shoko
Department of Food and Life-science, Takasaki University of Health and Welfare
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Kobayashi S
Department Of Food And Life-science Takasaki University Of Health And Welfare
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Konishi Yutaka
Applied Bioresearch Center Research & Development Department Kirin Brewery Co. Ltd.
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Konishi Yutaka
Applied Bioresearch Center Research & Development Department
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Kobayashi Shoko
Department Of Food And Life Science Takasaki University Of Health And Welfare
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Konishi Yutaka
Applied Bioresearch Center Kirin Brewery Co. Ltd.
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Shimizu Makoto
Department Of Applied Biological Chemistry The University Of Tokyo
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Shimizu Makoto
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Kobayashi Shoko
Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital
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