A Novel Method for Producing a Foodstuff from Defatted Black Sesame Seed That Inhibits Allergen Absorption
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概要
- 論文の詳細を見る
A method is proposed to produce a foodstuff that inhibits allergen absorption through the intestinal tract. Defatted black sesame (Sesamum indicum) seeds as a starting material were hydrolyzed with a crude preparation of trypsin at 40°C and pH 8 for 3 hrs while gently stirring to generate an active peptide. The resulting hydrolysate was heated to inactivate the trypsin and make the active components soluble. An extract was obtained by centrifugation and then freeze-dried. Ser-Asn-Ala-Leu-Val-Ser-Pro-Asp-Trp-Ser-Met-Thr-Gly-His (compound 1) as an active peptide, and sesamino1 2′-O-β-glucopyranosyl-(1→2)-O-[β-glucopyranosyl(1→6)]-O-β-glucopyranoside (compound 2) and sesamino1 2′-O-β-glucopyranosyl (1→2)-O-β-glucopyranoside (compound 3) were identified as active lignan glycosides in an in vitro model by using Caco-2 cells. Compound 1 was active at 10−7 M and compounds 2 and 3 at 10−5 M.
- 社団法人 日本農芸化学会の論文
- 2004-02-23
著者
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WATANABE Jun
Food Function Division, National Food Research Institute
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FUKUSHI Eri
Graduate School of Agriculture, Hokkaido University
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KAWABATA Jun
Graduate School of Agriculture, Hokkaido University
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Kawabata J
Hokkaido Univ. Sapporo Jpn
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Kawabata Jun
Lab. Of Food Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido Univ.
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Kawabata Jun
Graduate School Of Agriculture Hokkaido University
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KOBAYASHI Shoko
Department of Food and Life-science, Takasaki University of Health and Welfare
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SHINMOTO Hiroshi
Food Function Division, National Food Research Institute
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Kawabata Jun
Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Kobayashi S
Department Of Food And Life-science Takasaki University Of Health And Welfare
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Fukushi E
Graduate School Of Agriculture Hokkaido University
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Fukushi Eri
Graduate School Of Agriculture Hokkaido University
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Watanabe J
Food Function Division National Food Research Institute
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Kobayashi Shoko
Department Of Food And Life Science Takasaki University Of Health And Welfare
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Shinmoto Hiroshi
Food Function Division National Food Research Institute
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Watanabe Jun
Food Function Division National Food Research Institute
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Kobayashi Shoko
Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital
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