An Active Compound against Allergen Absorption in Hypoallergenic Wheat Flour Produced by Enzymatic Modification(Food & Nutrition Science)
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概要
- 論文の詳細を見る
Hypoallergenic wheat flour produced by modification with cellulase and actinase showed inhibitory activity against ovalbumin permeation in an in vitro model by using the Caco-2 cell monolayer. The activity was found in the cellulase preparation used for producing the flour. An active compound was isolated by HPLC and identified as Trp-Ser-Asn-Ser-Gly-Asn-Phe-Val-Gly-Gly-Lys by ^1H-NMR data and Edman degradation. The undecapeptide, some oligopeptides with the N-terminal sequences and Trp ethyl ester showed activity at 10^<-7>M, acetyl Trp being active at 10^<-2>M. These data suggestthat the Trp residue without a free carboxyl group would be required for the inhibitory activity of ovalbumin absorption through the intestinal tract.
- 社団法人日本農芸化学会の論文
- 2002-09-23
著者
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Sonoyama K
Hokkaido Univ. Sapporo Jpn
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Sonoyama Kei
Graduate School Of Agriculture Hokkaido University
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WATANABE Jun
Graduate School of Agriculture, Hokkaido University
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FUKUSHI Eri
Graduate School of Agriculture, Hokkaido University
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KAWABATA Jun
Graduate School of Agriculture, Hokkaido University
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WATANABE Michiko
Department of Neurovirology, Research Institute for Microbial Diseases, Osaka University
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Kawabata J
Hokkaido Univ. Sapporo Jpn
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Kawabata Jun
Lab. Of Food Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido Univ.
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Kawabata Jun
Graduate School Of Agriculture Hokkaido University
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TESAKI Shoko
Department of Nutrition and Life-science, Takasaki University of Health and Welfare
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TANABE Soichi
Faculty of Applied Biological Science, Hiroshima University
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Watanabe M
Faculty Of Agriculture Tokyo University Of Agriculture And Technology
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Kawabata Jun
Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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田辺 創一
広島大学大学院生物圏科学
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Watanabe M
Department Of Health And Nutrition Takasaki University Of Health And Welfare
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Fukushi E
Graduate School Of Agriculture Hokkaido University
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Fukushi Eri
Graduate School Of Agriculture Hokkaido University
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Watanabe J
Food Function Division National Food Research Institute
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Tesaki Shoko
Department Of Nutrition And Life-science Takasaki University Of Health And Welfare
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Watanabe M
Tokyo Univ. Agriculture And Technology Tokyo Jpn
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田辺 創一
広島大学大学院生物圏科学研究科
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Tanabe Soichi
Graduate School Of Biosphere Sci. Hiroshima Univ.
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Watanabe Michiko
Department Of Agricultural Chemistry The University Of Tokyo
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