Total Solution Synthesis of Human Epidermal Growth Factor (h-EGF) by the Assembly of Nine Building Blocks

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概要

• 論文の詳細を見る

• Human epidermal growth factor (h-EGF) composed of 53 amino acids bearing three intramolecular disulfide bridges was synthesized by the maximum protecting solution method. The synthetic h-EGF coincided with recombinant h-EGF by reverse-phase HPLC, and the sites of three intramolecular disulfide bridges were ascertained by a thermolytic digestion. The synthetic h-EGF possessed m/z 6215.7 in its FAB-MS as expected, and exhibited compatible mitogenic activity.

• 社団法人日本農芸化学会の論文
• 1992-03-23

著者

• MUNEKATA Eisuke

  Institute of Applied Biochemistry, University of Tsukuba

• Watanabe M

  Faculty Of Agriculture Tokyo University Of Agriculture And Technology

• WATANABE Masanori

  Institute of Gastroentorology, Nippon Medical School Musashikosugi Hospital

• Shin S

  Univ. Tsukuba Tsukuba Jpn

• Shin Song

  Institute Of Applied Biochemistry University Of Tsukuba

• Shin Song

  Research Center For Proteineous Materials (rcpm) Chosun University

• Munekata E

  Institute Of Applied Biochemistry University Of Tsukuba

• Munekata Eisuke

  Institute Of Applied Biochemistry Tsukuba University

• KABURAKI Yukihiko

  Institute of Applied Biochemistry, University of Tsukuba

• Kaburaki Yukihiko

  Institute Of Applied Biochemistry University Of Tsukuba

• Watanabe Masanori

  Institute Of Gastroentorology Nippon Medical School Musashikosugi Hospital

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