Inhibition of Angiotensin-converting Enzyme by Synthetic Peptides of Human β-Casein(Biological Chemistry)

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概要

• 論文の詳細を見る

• The possible roles of caseins as exorphins, immunostimulants and hypotensive agents have recently been suggested by several groups. In an attempt to prove the existence and to elucidate the physiological significance of peptide inhibitors of angiotensin-converting enzyme (ACE) in milk proteins, we synthesized a total of 69 peptide fragments of human β-casein, in which a proline residue was placed at the C-terminus for the ACE inhibitory activity. It was found that the peptides with potent inhibitory activity in vitro were located in the region of amino acid residues 39〜52 of human β-casein. All the peptides within this sequence (39〜52) had potent ACE inhibitory activity. The most potent inhibitor was a decapeptide, Ser-Phe-Gln-Pro-Gln-Pro-Leu-Ile-Tyr-Pro (IC_<50>=1.4μM), which was also active in vivo.

• 社団法人日本農芸化学会の論文
• 1989-08-23

著者

• MUNEKATA Eisuke

  Institute of Applied Biochemistry, University of Tsukuba

• Nio Noriki

  Central Research Laboratories, Ajinomoto Co., Inc.

• Ariyoshi Yasuo

  Central Research Laboratories, Ajinomoto Co., Inc.

• Nio N

  Ajinomoto Co. Inc. Kanagawa Jpn

• Ariyoshi Y

  Ajinomoto Co. Inc. Kawasaki Jpn

• Ariyoshi Yasuo

  Central Research Laboratories Ajinomoto Co. Inc

• Kohmura M

  Ajinomoto Co. Inc. Kawasaki Jpn

• Kohmura Masanori

  Central Research Laboratories, Ajinomoto Co., Inc.

• KUBO Kazuki

  Institute of Applied Biochemistry, University of Tsukuba

• MINOSHIMA Yumi

  Institute of Applied Biochemistry, University of Tsukuba

• Kubo Kazuki

  Institute Of Applied Biochemistry University Of Tsukuba

• Minoshima Yumi

  Institute Of Applied Biochemistry University Of Tsukuba

• Munekata Eisuke

  Institute Of Applied Biochemistry Tsukuba University

• Kohmura Masanori

  Central Research Laboratories Ajinomoto Co. Inc.

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