Inhibition of Prolyl Endopeptidase by Synthetic Peptide Fragments of Human β-Casein(Food & Nutrition)
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概要
- 論文の詳細を見る
It has been suggested that peptide inhibitors of prolyl endopeptidase(PEP) may act as anti-amnestic agents. In the hope of finding PEP inhibitors in milk proteins, we synthesized a totalof 37 human β-casein peptide fragments containing proline residues. It was found that the peptides with PEP inhibition activity in vitro were located in the region of amino acid residues 49-59 of human β-casein. The most potent inhibitor was Ile-Tyr-Pro-Phe-Val-Glu-Pro-Ile(IC_<50>=8μM).
- 社団法人日本農芸化学会の論文
- 1991-03-23
著者
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Nio Noriki
Central Research Laboratories, Ajinomoto Co., Inc.
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Ariyoshi Yasuo
Central Research Laboratories, Ajinomoto Co., Inc.
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Asano Mitsuko
Department Of Agricultural Chemistry The University Of Tokyo
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Nio N
Ajinomoto Co. Inc. Kanagawa Jpn
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Asano Minao
Central Research Laboratories Ajinomoto Co. Inc.
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Ariyoshi Y
Ajinomoto Co. Inc. Kawasaki Jpn
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Ariyoshi Yasuo
Central Research Laboratories Ajinomoto Co. Inc
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