Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60
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概要
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NoteThe apoptosis-inducing effect of fucoxanthin on human leukemic HL-60 cells was investigated. Fucoxanthin, which was obtained from the brown alga Undaria pinnatifida, inhibited the proliferation of HL-60 cells and induced DNA fragmentation on agarose gel electrophoresis, a typical characteristic feature of apoptotic cells. The results of sandwich ELISA using anti-biotin-antibody and anti-DNA-antibody also demonstrated DNA fragmentation in accordance with the increase in fucoxanthin concentration and incubation time. Since the level of DNA fragmentation did not increase after 24 h incubation, fucoxanthin appeared to have some effect on cell cycle. In contrast, β-carotene did not show an apoptosis-inducing effect on HL-60 cells. These results suggested that a carotenoid structure might be crucial for inducing apoptosis.
- Japanese Society for Food Science and Technologyの論文
- 1999-08-01
著者
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KOHNO Hiroyuki
Department of Oncologic Pathology, Kanazawa Medical University
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Kohno H
Department Of Oncologic Pathology Kanazawa Medical University
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HOSOKAWA Masashi
Faculty of Fisheries, Hokkaido University
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KURIHARA Hideyuki
Faculty of Fisheries, Hokkaido University
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ODASHIMA Shizuo
Department of Pathology, Kanazawa Medical University
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TAKAHASHI Koretaro
Faculty of Fisheries, Hokkaido University
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Odashima Shizuo
Department Of Pathology Kanazawa Medical University
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Odashima Shizuo
金沢医科大学総合医学研究所
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Odashima Shizuo
Department Pathology Kanazawa Medical University
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Kurihara Hideyuki
Div. Of Marine Life Sci. Graduate School Of Fisheries Sciences Hokkaido Univ. 3-1-1 Minato-cho Hakod
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Hosokawa M
Faculty Of Fisheries Sciences Hokkaido University
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WANEZAKI Satoshi
Faculty of Fisheries, Hokkaido University
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MIYAUCHI Kozue
Faculty of Fisheries, Hokkaido University
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KAWABATA Jun
Faculty of Agriculture, Hokkaido University
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Kohno Hiroyuki
Department Pathology Kanazawa Medical University
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Kawabata J
Hokkaido Univ. Sapporo Jpn
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Kawabata Jun
Lab. Of Food Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido Univ.
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Kawabata Jun
Graduate School Of Agriculture Hokkaido University
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Takahashi Koretaro
Faculty Of Fisheries Hokkaido University
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Miyauchi Kozue
Faculty Of Fisheries Hokkaido University
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Wanezaki Satoshi
Faculty Of Fisheries Hokkaido University
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Kawabata Jun
Bioscience And Chemistry Faculty Of Agriculture Hokkaido University
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Hosokawa Masashi
Faculty Of Fisheries Hokkaido University
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Hosokawa Masashi
Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish
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Hideyuki Kurihara
Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University
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Kohno Hiroyuki
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Kurihara Hideyuki
Hokkaido Univ. Hakodate Jpn
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Takahashi Koretaro
Div. Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido Univ.
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Takahashi K
Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University
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Kawabata Jun
Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai
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Kurihara H
Graduate School Of Fisheries Sciences Hokkaido University
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Kurihara H
Gunma Univ. Gunma Jpn
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KOHNO Hiroyuki
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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