Suppressive Effect of Neoxanthin on the Differentiation of 3T3-L1 Adipose Cells
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概要
- 論文の詳細を見る
The objective of this study was to assess the suppressive effects of 13 naturally occurring carotenoids on the adipocyte differentiation of 3T3-L1. The relationship between carotenoid structure and suppressive effects was also examined. Treatment with neoxanthin significantly reduced lipid accumulation, as well as glycerol-3-phosphate dehydrogenase activity. This suppressive effect on adipose cell differentiation was not observed in the other 12 carotenoids used in this study. Neoxanthin treatment also decreased expression of CCAAT/enhancer binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) mRNAs. An examination of structure and function suggested that carotenoids containing an allene bond and an additional hydroxyl substituent on the side group may show suppressive effects on adipocyte differentiation in 3T3-L1 cells.
著者
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Hosokawa Masashi
Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish
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Miyashita Kazuo
Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioresources Graduate School Of Fi
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Okada Tomoko
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries
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Nakai Miho
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries
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Maeda Hayato
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries
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Sashima Tokutake
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries
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Miyashita Kazuo
Laboratory of Bio-functional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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Okada Tomoko
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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SASHIMA Tokutake
Laboratory of Bio-functional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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Sashima Tokutake
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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HOSOKAWA Masashi
Laboratory of Bio-functional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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Hosokawa Masashi
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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Nakai Miho
Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Faculty of Fisheries Sciences, Hokkaido University
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