Increase in Deformability of Human Erythrocytes through the Action of β-Lysophospholipid Rich in n-3 Polyunsaturated Fatty Acid Content
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概要
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報文Lysophosphatidylcholine (LPC) that binds to docosahexaenoic acid (DHA) at the sn-2 position (β-DHA-LPC) was prepared by the Lipozyme mediated selective partial hydrolysis of DHA-enriched egg yolk lecithin. The β-DHA-LPC was found to be rapidly incorporated into erythrocyte cells and increase their deformability at 5μM/erythrocyte.リポザイム（ケカビ由来固定化酵素）を用いたドコサヘキサエン酸 (DHA) 強化鶏卵黄ホスファチジルコリン (PC) の選択的部分加水分解反応により，sn-2位にDHAの結合したリゾホスファチジルコリン (β-DHA-LPC) を調製した。このβ-DHA-LPCは，ヒト赤血球懸濁液に対し5μMの濃度においても，速やかにヒト赤血球中に取り込まれ，その変形能を向上させることができることを人工毛細血管モデルにより明らかにした。
- 日本油化学会 = Japan Oil Chemists' Societyの論文
- 1998-12-01
著者
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HOSOKAWA Masashi
Faculty of Fisheries, Hokkaido University
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TAKAHASHI Koretaro
Faculty of Fisheries, Hokkaido University
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Takahashi Koretaro
Faculty Of Fisheries Hokkaido University
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ONO Masayo
Faculty of Fisheries, Hokkaido University
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INOUE Yoshikazu
Bizen Chemical Co., Ltd.
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Ono Masayo
Faculty Of Fisheries Hokkaido University
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Hosokawa Masashi
Faculty Of Fisheries Hokkaido University
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Hosokawa Masashi
Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish
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Takahashi Koretaro
Div. Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido Univ.
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Takahashi K
Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University
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Hosokawa M
Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University
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Inoue Yoshikazu
Bizen Chemical Co. Ltd.
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Inoue Yoshikazu
Bizen Chemical Co.
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細川 雅史
Faculty of Fisheries, Hokkaido University
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小野 雅代
Faculty of Fisheries, Hokkaido University
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高橋 是太郎
Faculty of Fisheries, Hokkaido University
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