Butyrate-Induced Growth Inhibition and Differentiation in Caco-2 Cells with Hybrid Liposomes

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概要

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• Hybrid liposomes were prepared by mixing glycerophospholipids with glyceroglycolipids. The effects of hybrid liposomes on Caco-2 cells were investigated. Growth inhibition of cells was determined with sodium 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium dye reduction assay. Alkaline phosphatase activity was measured for assessing the cell differentiation induced by sodium butyrate (NaBT). Growth of Caco-2 cells was inhibited at 48 h after addition of all four types hybrid liposomes (PC/DGDG, PC/SQDG, PS/DGDG and PS/SQDG) while at 72 h growth inhibition was significant for all treatments except the hybrid liposome of phosphatidylcholine and digalactosyldiacylglycerol under concentrations of 50 μM glycerophospholipids with 50 μM glyceroglycolipids. Alkaline phosphatase activity of Caco-2 cells increased significantly when cells were treated in combination of hybrid liposomes and NaBT at 72 h, indicating that hybrid liposomes enhanced cell differentiation induced with NaBT.

• Japan oil chemists' societyの論文

著者

• Kurihara Hideyuki

  Div. Of Marine Life Sci. Graduate School Of Fisheries Sciences Hokkaido Univ. 3-1-1 Minato-cho Hakod

• Hosokawa M

  Faculty Of Fisheries Sciences Hokkaido University

• Hossain Zakir

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Kurihara Hideyuki

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Hosokawa Masashi

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Takahashi Koretaro

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Takahashi Koretaro

  Faculty Of Fisheries Hokkaido University

• Hossain Zakir

  Div. Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido Univ.

• Hosokawa Masashi

  Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish

• Hideyuki Kurihara

  Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University

• Kurihara Hideyuki

  Hokkaido Univ. Hakodate Jpn

• Takahashi Koretaro

  Div. Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido Univ.

• Takahashi K

  Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University

• Hosokawa M

  Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University

• Kurihara H

  Graduate School Of Fisheries Sciences Hokkaido University

• Kurihara H

  Gunma Univ. Gunma Jpn

• Hossain Zakir

  Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University

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