Therapy of Myeloma In Vivo Using Marine Phospholipid in Combination with Agaricus blazei Murill as an Immune Respond Activator

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概要

• 論文の詳細を見る

• Mushroom (Agaricus blazei Murill) extract has been reported to possess antitumor effects through immune activation. Here, we investigated the beneficial effects of combining A. blazei extract with marine phospholipids in comparison to A. blazei extract alone on myeloma sp2 tumor suppression when orally administrated. The experimental groups designed for sp2 tumor bearing BALB/c nu/nu mice were drinks of: (1)control; (2)1.0 mg/mL squid phospholipid liposome alone; (3)0.5 mg/mL A. blazei Murill water extract alone; (4)1.0 mg/mL squid phospholipid liposome with 0.5 mg/mL A. blazei Murill water extract in the form of those simple mixture; and (5)1.0 mg/mL squid phospholipid liposome with 0.5 mg/mL A. blazei Murill water extract partially encapsulated. Orally administrated volumes amounted to approximately 5 mL per day per mouse for all groups. A. blazei Murill water extract alone and squid phospholipid alone served groups show moderate tumor suppression with total administrations of approximately 105 mg/mouse for squid phospholipid through out the experimental term. When both A. blazei Murill water extract and squid phospholipid were administrated simultaneously in a simple mixture form, promotional effect on cancer tumor suppression was observed. And when A. blazei Murill water extract was partially encapsulated in the squid phospholipid liposomes with total administrations being 105 mg/mouse for squid phospholipid, effect on cancer tumor suppression was more pronounced. Though there was no statistically significant difference in tumor sizes between the simple mixture form administrated group i.e. group (4) and the partially encapsulated form administrated group i.e. group (5), the tumor vanished mouse was seen in the partially encapsulated form administrated group. Thus it was concluded that combinational administration of the A. blazei Murill water extract and the marine phospholipid may be useful in myeloma sp2 therapy.

• 日本油化学会の論文

著者

• FUKUNAGA Kenji

  Faculty of Chemistry, Materials and Bioengineering, Kansai University

• Hossain Zakir

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Hosokawa Masashi

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Takahashi Koretaro

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Fukunaga Kenji

  Faculty Of Chemistry Materials And Bioengineering Kansai University

• Murakawa Kentaro

  Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University

• Tanouchi Masatoshi

  Cosmo Food Ltd.

• Hossain Zakir

  Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University

• Fukunaga Kenji

  Faculty of Engineering, Kansai University

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