Effect of Phospholipids Containing Docosahexaenoic Acid on Differentiation and Growth of HL-60 Human Promyelocytic Leukemia Cells

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概要

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• Effects of docosahexaenoic acid (DHA)-containing phospholipids (DHA-PLs) on retionic acid (RA)-induced cell differentiation and growth inhibition of the human promyelocytic leukemia cell line, HL-60 were investigated. Cell differentiation judged from NBT reduction assay reached to 50~60% by incubation with 12.5μM DHA-containing phosphatidylcholines (DHA-PCs) prior to the addition of RA. Differentiation without DHA-PCs remained at 39.2%. By prior incubation with DHA-containing phosphatidylethanolamines (DHA-PEs), differentiation was 70% at 12.5μM. DHA-PEs induced NBT reducing activity to as much as 20~30%, and inhibited cell growth in the absence of RA. Activity for promoting cell differentiation differed according to DHA-PL molecular species. 1-Palmitoyl (or oleoyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine (or phosphoethanolamine) was found most effective molecular species for enhancing RA-induced cell differentiation.ヒト前骨髄性白血病細胞（HL-60細胞）の分化と増殖に及ぼすドコサヘキサエン酸 (DHA) 結合型リン脂質の影響について検討した。分化誘導剤であるレチノイン酸 (RA) の単独添加に比べ，DHA結合型ホスファチジルコリンでインキュベーションした後にRAを添加することで分化率が有意に上昇した。このようなRAの分化誘導能に対する促進効果は，sn-1位がパルミチン酸又はオレイン酸，sn-2位がDHAである分子種において顕著であった。同一分子種のホスファチジルエタノールアミン (PE) の添加では，ホスファチジルコリンに比べより大きな分化誘導促進効果がみられ，DHA結合型PEのみを単独添加した場合においても，強い細胞増殖抑制作用とNBT還元能の上昇がみられた。以上の結果より，HL-60細胞の分化誘導および増殖抑制に対して，1-palmitoyl又は1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamineが最も効果的であった。

• 1997-04-20

著者

• KOHNO Hiroyuki

  Department of Oncologic Pathology, Kanazawa Medical University

• TOCHIZAWA Kaoru

  Faculty of Fisheries, Hokkaido University

• HOSOKAWA Masashi

  Faculty of Fisheries, Hokkaido University

• KURIHARA Hideyuki

  Faculty of Fisheries, Hokkaido University

• ODASHIMA Shizuo

  Department of Pathology, Kanazawa Medical University

• TAKAHASHI Koretaro

  Faculty of Fisheries, Hokkaido University

• Tochizawa Kaoru

  Faculty Of Fisheries Hokkaido University

• Odashima Shizuo

  Department Of Pathology Kanazawa Medical University

• Odashima Shizuo

  金沢医科大学総合医学研究所

• Odashima Shizuo

  Department Pathology Kanazawa Medical University

• Kurihara Hideyuki

  Div. Of Marine Life Sci. Graduate School Of Fisheries Sciences Hokkaido Univ. 3-1-1 Minato-cho Hakod

• Hosokawa M

  Faculty Of Fisheries Sciences Hokkaido University

• Kohno Hiroyuki

  Department Pathology Kanazawa Medical University

• Takahashi Koretaro

  Faculty Of Fisheries Hokkaido University

• Hosokawa Masashi

  Faculty Of Fisheries Hokkaido University

• Hosokawa Masashi

  Laboratory Of Biofunctional Material Chemistry Division Of Marine Bioscience Craduate School Of Fish

• Hideyuki Kurihara

  Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University

• Kohno Hiroyuki

  Department Of Chemistry Faculty Of Science Science University Of Tokyo

• Kurihara Hideyuki

  Hokkaido Univ. Hakodate Jpn

• Takahashi Koretaro

  Div. Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido Univ.

• Takahashi K

  Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University

• Hosokawa M

  Department Of Marine Bioresources Chemistry Faculty Of Fisheries Hokkaido University

• Kurihara H

  Graduate School Of Fisheries Sciences Hokkaido University

• Kurihara H

  Gunma Univ. Gunma Jpn

• 栃沢 馨

  Faculty of Fisheries, Hokkaido University

• 細川 雅史

  Faculty of Fisheries, Hokkaido University

• 栗原 秀幸

  Faculty of Fisheries, Hokkaido University

• KOHNO Hiroyuki

  Department of Chemical Pharmacology, Tohoku College of Pharmacy

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