Spermine Modulates Calcium Flux through the Rat Erythrocyte Membrane
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概要
- 論文の詳細を見る
The uptake of ^<45>Ca by inside-out erythrocyte membrane vesicles (IOV) was dose-dependently inhibited by spermine. A cationic substance, Mg^<2+>, did not affect this inhibitory activity of spermine. Ca^<2+>-ATPase activity, however, was not inhibited by spermine at a concentration that could inhibit the uptake of ^<45>Ca by the IOV. The release of ^<45>Ca from IOV was significantly accelerated by spermine. Spermine bound to the surface of the IOV and was removed by treatment with acetic acid. These results suggest that spermine stimulates the release of Ca^<2+> from the IOV (or uptake of Ca^<2+> by erythrocytes) via an effect on the outer surface of the IOV (or the inner surface of erythrocytes).
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
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KOHNO Hiroyuki
Department of Oncologic Pathology, Kanazawa Medical University
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OHKUBO Yasuhito
Department of Radiopharmacology, Tohoku Pharmaceutical University
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Ohkubo Yasuhito
Department Of Radiopharmacology Tohoku Pharmaceutical University
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Ohkubo Yasuhito
Department Of Radiopharmacy Tohoku College Of Pharmacy
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Kohno Hiroyuki
Department Of Radiopharmacy Tohoku College Of Pharmacy
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Kohno Hiroyuki
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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SASAKI Katsuya
Department of Radiopharmacy, Tohoku College of Pharmacy
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YAMAGUCHI Mikie
Department of Radiopharmacy, Tohoku College of Pharmacy
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Sasaki Katsuya
Department Of Radiopharmacy Tohoku College Of Pharmacy
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Yamaguchi Mikie
Department Of Radiopharmacy Tohoku College Of Pharmacy
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KOHNO Hiroyuki
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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