Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice(Biochemistry/Molecular Biology)

概要

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Gallium-67 (^<67>Ga) has been used as a tumor or inflammation-imaging agent in nuclear medicine. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl_4) treatment in rats. However, the peak of ^<67>Ga uptake by the liver tissue and hepatocytes was 2 d after the treatment. If ^<67>Ga is taken in the hepatic disorder phase, the pattern of ^<67>Ga uptake by the hepatocytes should be consistent with that of the ALT level. In order to answer why it was not, we carried out a detailed examination. The lipid peroxidation of hepatocytes from CCl_4-treated mice was greatly increased 1 d after CCl_4 treatment ; serum ALT was also increased 1 d after the treatment. The uptake of ^<67>Ga by the liver tissue reached a maximum 1 and 2 d after the treatment, while maximum by the hepatocytes was achieved after 2 d. The incorporation of bromodeoxyuridine into the hepatocytes also reached maximum 2 d after the treatment. These results suggest that the uptake of ^<67>Ga by the hepatocytes is carried out during liver regeneration rather than during hepatic disorder by CCl_4 treatment.
公益社団法人日本薬学会の論文
2004-12-01