Oxidative Stress Induced Lipocalin 2 Gene Expression : Addressing its Expression under the Harmful Conditions

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概要

• 論文の詳細を見る

• Lipocalin 2 (Lcn2, NGAL) is a member of the lipocalin superfamily with diverse functions such as the transport of fatty acids and the induction of apoptosis. Previous reports indicated that expression of Lcn2 is induced under harmful conditions. However, the mechanisms of the induction of Lcn2 expression remain to be elucidated. In this report, we intended to identify the factor or factors that induce Lcn2 expression. Up-regulation of Lcn2 expression after X-ray exposure was detected in the heart, the kidney and especially in the liver. Primary culture of liver component cells revealed that this up-regulation in the liver was induced in hepatocytes. Up-regulation of Lcn2 expression was also detected in HepG2 cells after the administration of X-rays or H_2O_2. Interestingly, up-regulation of Lcn2 expression after H_2O_2 treatment was canceled by the addition of the anti-oxidants, dimethylsulfoxide or cysteamine. These results strongly suggest that Lcn2 expression is induced by reactive oxygen species. Therefore, Lcn2 could be a useful biomarker to identify oxidative stress both in vitro and in vivo.

• 日本放射線影響学会の論文
• 2007-01-15

著者

• KUWAHARA Yoshikazu

  Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University

• FUKUMOTO Manabu

  Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University

• OHTAKE Yosuke

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• OHKUBO Yasuhito

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• Fukumoto Manabu

  Department Of Pathology Institute Of Development Aging And Cancer Tohoku University

• Kuwahara Yoshikazu

  Department Of Pathology Institute Of Development Aging And Cancer Tohoku University

• Ohtake Yosuke

  Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.

• Fukuoka Masako

  岡山大学 薬学部 衛生代謝解析学

• ABE Shinya

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Fukumoto Manabu

  Dept. Pathol. Idac. Tohoku Univ.

• Fukumoto M

  First Department Of Pathology School Of Medicine Kyoto University

• Ohuchi Yukie

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• BABA Taisuke

  Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University

• ROUDKENAR Mehryar

  Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University

• Ohkubo Yasuhito

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Abe Shinya

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Fukumoto Manabu

  Department Of Pathology And Biology Of Disease Faculty Of Medicine Kyoto University

• 大窪 芳子

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Baba Taisuke

  Department Of Pathology Institute Of Development Aging And Cancer Tohoku University

• ROUSHANDEH Amaneh

  Department of Anatomy, Medicine Faculty, Medical University of Tabriz

• EBISHIMA Shigeko

  Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University

• Ebishima Shigeko

  Department Of Pathology Institute Of Development Aging And Cancer Tohoku University

• Roudkenar Mehryar

  Department Of Pathology Institute Of Development Aging And Cancer Tohoku University:research Center

• Roushandeh Amaneh

  Department Of Anatomy Medicine Faculty Medical University Of Tabriz

• Abe Shinya

  Department Of Cardiology Tobu Chiiki Hospital Tokyo Metropolitan Health And Medical Treatment Corpor

• Taisuke ROUSHANDEH

  Department of Anatomy, Medicine Faculty, Medical University of Tabriz

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