The Entering of Indium-111 and Iron-59 into the Hepatocytes from Partially Hepatectomized Rats Differ from That of Gallium-67(Biochemistry/Molecular Biology)

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We recently suggested that the transferrin (Tf)-gallium-67 (^<67>Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free ^<67>Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (^<111>In) and iron-59 (^<59>Fe) with high affinity to transferrin differed from the entering of ^<67>Ga by the hepatocytes after partial hepatectomy. ^<111>In was almost taken by the plasma and little taken by the red blood cell. On the other hand, the uptake of ^<59>Fe by the red blood cell was higher than plasma. The uptake of ^<59>Fe by the bone marrow was significantly higher than that of ^<111>In. The uptake of ^<111>In and ^<59>Fe by the liver tissue was reached a maximum 2 d after partial hepatectomy but the uptake ratio of ^<111>In was lower than that of ^<59>Fe. We suspected that the uptake of ^<59>Fe by the liver tissue was the highest because of the high binding affinity of Tf-^<59>Fe to Tf-receptor. The entering of ^<111>In and ^<59>Fe into the hepatocytes was also reached a maximum 2 d after partial hepatectomy but the ratio of ^<59>Fe was slightly lower than that of ^<111>In. These results suggested that the binding affinity to Tf could have played a crucial role in the differences of the entering of ^<111>In, ^<59>Fe and ^<67>Ga into the hepatocytes of partially hepatectomized rats.
公益社団法人日本薬学会の論文
2004-08-01