The Effect of Blood Decrease on ^<67>Ga Uptake by the Liver in Partially Hepatectomized Rats(Biopharmacy)

概要

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As ^<67>Ga is injected into the blood, ^<67>Ga is immediately bound to transferrin (Tf) and transported to various tissues and the Tf-^<67>Ga complex binds to Tf receptor on various tissues. In partial hepatectomy (PH) a part of blood in circulation is lost together with removed liver tissues, consequently the amounts of blood cells and Tf in circulation decrease. In order to investigate the effect of those decreases on ^<67>Ga uptake by the liver, we compared the uptake in partially hepatectomized rats with that in venesectioned rats in which only a part of blood in circulation decreased. A two-thirds PH was performed. Two milliliters of blood was venesectioned. Each treated rat was intraveneously injected with ^<67>Ga. The changes of erythrocyte and reticulocyte contents after PH did not differ from those after venesection (VS) at all. But ^<67>Ga uptake by reticulocytes significantly increased after VS but did not after PH. On the other hand, ^<67>Ga uptake by the liver significantly increased after PH but did not after VS. These differences must be related to the different expression of Tf receptors on the liver after PH and VS.
公益社団法人日本薬学会の論文
2007-05-01