The Involvement of Transferrin in the Uptake of Iron-59 by Hepatocytes of Carbon Tetrachloride-Damaged Rats(Pharmacology)

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概要

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• We have reported that transferrin (Tf)-unbound Gallium-67 (^<67>Ga) was taken up into hepatocytes 1d after carbon tetrachloride (CCl_4)-treatment in rats. It had been reported that the binding affinity of Iron-59 (^<59>Fe) to Tf was greater than that of ^<67>Ga. In the present study, we investigated whether or not Tf was involved in ^<59>Fe uptake by hepatocytes of CCl_4-damaged rats. The results showed that the uptake of ^<59>Fe by hepatocytes and the number of Tf-receptor decreased 1d after CCl_4-treatment and increased 2d after the treatment. Our data demonstrated that the uptake of ^<59>Fe by hepatocytes differed from that of ^<67>Ga and Tf was involved in that of ^<59>Fe. We expect that these finding could serve to analyze the inflammatory stages, disorder stage at 1d and regeneration stage at 2d after CCl_4-treatment.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• OHTAKE Yosuke

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• OHKUBO Yasuhito

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• Ohtake Yosuke

  Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.

• ABE Shinya

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Inoue Yoshihiro

  Department of Radiology, Mitsui Memorial Hospital

• Satoh Satoko

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohuchi Yukie

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohkubo Yasuhito

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Abe Shinya

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• 大窪 芳子

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohtake Yosuke

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Suyama Satoko

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• TOUKAIRIN Ai

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Toukairin Ai

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Inoue Yoshihiro

  Department Of Critical Care Medicine Iwate Medical University School Of Medicine

• Abe Shinya

  Department Of Cardiology Tobu Chiiki Hospital Tokyo Metropolitan Health And Medical Treatment Corpor

• Inoue Yoshihiro

  Department Of Critical Care Medicine Iwate Medical University

• Inoue Yoshihiro

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• INOUE YOSHIHIRO

  Department of Anatomy, Okayama University School of Dentistry

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