Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats(Pharmacology)

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概要

• 論文の詳細を見る

• We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl_4 treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl_4 treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl_4 in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to in- crease TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl4-treated animals was due to the different TGase activity that increased membrane stability.

• 社団法人日本薬学会の論文
• 2004-02-01

著者

• Nagase Satoru

  東北大学 医学部産婦人科

• Iwasaki Koichi

  Department of Environmental Science & Technology, Faculty of Agriculture, Kagoshima University

• OHTAKE Yosuke

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• OHKUBO Yasuhito

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• Ohtake Yosuke

  Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.

• Iwasaki K

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Iwasaki Koichi

  Laboratory Of Agricultural Systems Engineering

• SATO Naoko

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• ABE Shinya

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• YAMADA Takehito

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Sato N

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• YAMADA Tatsuhiko

  Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,

• Ohuchi Yukie

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohkubo Yasuhito

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Abe Shinya

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Yamada T

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• 大窪 芳子

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohtake Yosuke

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Nagase Satoru

  Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine

• Yamada Takehisa

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• Sato Naoko

  Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine

• Abe Shinya

  Department Of Cardiology Tobu Chiiki Hospital Tokyo Metropolitan Health And Medical Treatment Corpor

• Sato Naoko

  Department Of Applied Chemistry School Of Engineering The University Of Tokyo And Crest Japan Scienc

• Yamada Takehito

  Department Of Computer Science And Electronic Engineering Tokuyama College Of Technology

• Sato Naoaki

  Department Of Gynecology And Obstetrics Tohoku University Hospital

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