Development of an Experimental System for Evaluation of the Effect of Stress on Intestinal Motility Using a Radionuclide, ^<51>Cr, in the Rat
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概要
- 論文の詳細を見る
We attempted to develop an experimental system for evaluation of the influence of stress on small intestinal motility using a radionuclide, ^<51>Cr, and an acute restraint stress model. Each rat was immobilized in an adjustable restraint device for 1 to 5 h. The rat was given ^<51>Cr immediately after the end of stress loading through a catheter inserted into the duodenum, and sacrificed 20 min after administration. The small intestine was removed and the ^<51>Cr radioactivity was continuously monitored with an NaI-scintillation survey meter. The small intestinal motility was estimated by the distance of the radioactive peak from the top of the duodenum. The small intestinal motility was significantly inhibited by 3 h-restraint stress. This experimental system is easy, rapid, and simple for the evaluation of the effect of stress on small intestinal motility.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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TSUKADA Fumitake
Department of Radiopharmacy, Tohoku Pharmaceutical University
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Ohkubo Yasuhito
Department Of Radiopharmacology Tohoku Pharmaceutical University
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Tsukada Fumitake
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Tsukuda Fumitake
Department Of Radiopharmacy Tohoku Pharmaceutical University
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SAITOH Mizue
Department of Radiopharmacy, Tohoku Pharmaceutical University
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Saitoh Mizue
Department Of Radiopharmacy Tohoku Pharmaceutical University
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