Mechanism of Inhibition of Small Intestinal Motility by Restraint Stress Differs from That with Norepinephrine Treatment in Rats
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概要
- 論文の詳細を見る
We have previously reported that restraint stress inhibits small intestinal motility in rats, and that the adrenergic β_3-antagonist SR59230A administration recovered the inhibition. In the present study, we compared the effects of restraint stress and norepinephrine on small intestinal motility using α-and β-adrenergic antagonists. SR59230A did not recover the norepinephrine-induced inhibition of small intestinal motility. The norepinephrine-induced inhibition of small intestinal motility was recovered after administration of the α_2-antagonist yohimbine, but not by α_1-, β_1-, and β_2-antagonists. Considering these results, it is reasonable to assume that the mechanisms of inhibition of small intestinal motility due to restraint stress and norepinephrine treatment are different.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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KOHNO Hiroyuki
Department of Oncologic Pathology, Kanazawa Medical University
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Kohno Hiroyuki
東北薬科大学 放射薬品
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OHTAKE Yosuke
Department of Radiopharmacology, Tohoku Pharmaceutical University
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OHKUBO Yasuhito
Department of Radiopharmacology, Tohoku Pharmaceutical University
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Ohtake Yosuke
Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.
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Kohno H
Department Of Radiopharmacy Tohoku Pharmaceutical University
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TSUKADA Fumitake
Department of Radiopharmacy, Tohoku Pharmaceutical University
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SAWAMURA Kuniko
Department of Radiopharmacy, Tohoku Pharmaceutical University
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Ohuchi Yukie
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Sawamura Kuniko
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Ohkubo Yasuhito
Department Of Radiopharmacology Tohoku Pharmaceutical University
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Tsukada Fumitake
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Tsukada Fumitake
Department Of Radiophunnacy Tohoku Pharmaceutical University
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Kohno Hiroyuki
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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大窪 芳子
Department Of Radiopharmacy Tohoku Pharmaceutical University
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大窪 芳子
熊本大学 薬
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KOHNO Hiroyuki
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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