Zonal Differences in DNA Synthesis and in Transglutaminase Activity between Perivenous versus Periportal Regions of Regenerating Rat Liver(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
We investigated a relationship within zonal differences in DNA synthesis and in transglutaminase (TGase) activity between perivenous versus periportal regions of regenerating rat liver. Using the digitonin/collagenase per fusion technique, hepatocyte subpopulations were isolated from each region at various time points after partial hepatectomy. The amounts of DNA synthesis as well as the levels of TGase mRNA and activity in each subpopulation were measured. Although increased DNA synthesis was observed in both subpopulations with a peak at 24 h after partial hepatectomy, the amount of DNA synthesis in periportal hepatocytes (PPH) was twice as much as that in perivenous hepatocytes (PVH). In PVH, TGase activity peaked at 24 h after partial hepatectomy with a preceding increase in its mRNA expression at 12 h, whereas TGase activity in PPH at 24h was one-half of that in PVH. As TGase is known to have a growth-arresting activity, our data indicate that relatively higher TGase activity in PVH at 24 h after partial hepatectomy might correlate with relatively lower DNA synthesis in this region compared to periportal region.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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FUKUMOTO Manabu
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University
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Nagase Satoru
東北大学 医学部産婦人科
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OHTAKE Yosuke
Department of Radiopharmacology, Tohoku Pharmaceutical University
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OHKUBO Yasuhito
Department of Radiopharmacology, Tohoku Pharmaceutical University
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Fukumoto Manabu
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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Ohtake Yosuke
Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.
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Fukuoka Masako
岡山大学 薬学部 衛生代謝解析学
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SATO Naoko
Department of Radiopharmacy, Tohoku Pharmaceutical University
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ABE Shinya
Department of Radiopharmacy, Tohoku Pharmaceutical University
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Sato N
Department Of Radiopharmacy Tohoku Pharmaceutical University
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KOJIMA Soichi
Molecular Ligand Biology Research Team, Chemical Genomics Research Group, Chemical Biology Departmen
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Fukumoto Manabu
Dept. Pathol. Idac. Tohoku Univ.
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Fukumoto M
First Department Of Pathology School Of Medicine Kyoto University
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MARUKO Akiko
Department of Radiopharmacy, Tohoku Pharmaceutical University
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Satoh Satoko
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Maruko Akiko
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Ohuchi Yukie
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Ohkubo Yasuhito
Department Of Radiopharmacology Tohoku Pharmaceutical University
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Abe Shinya
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Fukumoto Manabu
Department Of Pathology And Biology Of Disease Faculty Of Medicine Kyoto University
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大窪 芳子
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Ohtake Yosuke
Department Of Radiopharmacology Tohoku Pharmaceutical University
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Kojima Soichi
Molecular Cellular Pathology Research Unit Riken
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Suyama Satoko
Department Of Radiopharmacy Tohoku Pharmaceutical University
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ONO Tomomi
Department of Radiopharmacy, Tohoku Pharmaceutical University
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NAGASHIMA Tomomi
Department of Radiopharmacy, Tohoku Pharmaceutical University
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Ono Tomomi
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Nagase Satoru
Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine
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Sato Naoko
Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine
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Ono Tomomi
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Kumamoto University
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Abe Shinya
Department Of Cardiology Tobu Chiiki Hospital Tokyo Metropolitan Health And Medical Treatment Corpor
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Sato Naoko
Department Of Applied Chemistry School Of Engineering The University Of Tokyo And Crest Japan Scienc
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Sato Naoaki
Department Of Gynecology And Obstetrics Tohoku University Hospital
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Nagashima T
Department Of Radiopharmacy Tohoku Pharmaceutical University
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