The Involvement of Polyamines as Substrates of Transglutaminase in Zonal Different Hepatocyte Proliferation after Partial Hepatectomy(Biochemistry/Molecular Biology)

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概要

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• We have recently demonstrated the inverse correlation between transglutaminase (TGase) activity and DNA synthesis in periportal hepatocytes (PPH) and perivenous hepatocytes (PVH) at 1 d after partial hepatectomy. In order to elucidate a role of polyamines as substrates of TGase in the differential growth capacities between PPH and PVH from regenerating liver, we investigated the zonal differences in alteration of ornithine decarboxylase (ODC) activity and polyamines. In two subpopulations, the inverse correlation between DNA synthesis and ε-(γ-glutamyl) lysine (Gln-Lys) cross-linking catalyzed by TGase was demonstrated at 1 d after partial hepatectomy. ODC activity in PPH significantly increased with a peak at 1 d after partial hepatectomy, whereas did not in PVH. Protein-binding SPD in PPH also transiently increased with a peak at 1 d after partial hepatectomy, but did not in PVH. These results suggest that at 1 d after partial hepatectomy, in PPH, the inhibition of Gln-Lys cross-linking by the formation of N-γ-glutamyl SPD leads to the increase of DNA synthesis, whereas in PVH, enhanced formation of Gln-Lys cross-linking leads to the lower DNA synthesis.

• 公益社団法人日本薬学会の論文
• 2005-02-01

著者

• FUKUMOTO Manabu

  Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University

• Nagase Satoru

  東北大学 医学部産婦人科

• OHTAKE Yosuke

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• OHKUBO Yasuhito

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• Fukumoto Manabu

  Department Of Pathology Institute Of Development Aging And Cancer Tohoku University

• Ohtake Yosuke

  Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.

• Fukuoka Masako

  岡山大学 薬学部 衛生代謝解析学

• SATO Naoko

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• ABE Shinya

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Sato N

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• KOJIMA Soichi

  Molecular Ligand Biology Research Team, Chemical Genomics Research Group, Chemical Biology Departmen

• Fukumoto Manabu

  Dept. Pathol. Idac. Tohoku Univ.

• Fukumoto M

  First Department Of Pathology School Of Medicine Kyoto University

• Satoh Satoko

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohuchi Yukie

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohkubo Yasuhito

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Abe Shinya

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Fukumoto Manabu

  Department Of Pathology And Biology Of Disease Faculty Of Medicine Kyoto University

• 大窪 芳子

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohtake Yosuke

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Kojima Soichi

  Molecular Cellular Pathology Research Unit Riken

• Suyama Satoko

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Nagase Satoru

  Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine

• Sato Naoko

  Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine

• Abe Shinya

  Department Of Cardiology Tobu Chiiki Hospital Tokyo Metropolitan Health And Medical Treatment Corpor

• Sato Naoko

  Department Of Applied Chemistry School Of Engineering The University Of Tokyo And Crest Japan Scienc

• Sato Naoaki

  Department Of Gynecology And Obstetrics Tohoku University Hospital

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