Development of an Experimental System for Evaluation of Stress Effect on Ethyl Alcohol Metabolism Using Radiorespirometric Analysis in Rat (Pharmacology)

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概要

• 論文の詳細を見る

• We attempted to develop an experimental system for evaluation of stress effect on ethyl alcohol metabolism by the radiorespirometric analysis using [^<14>C]ethyl alcohol. Each rat was immobilized in an adjustable restraint device for 3 h. The excretion of ^<14>CO_2 in the breath was significantly decreased by restraint stress. The liver alcohol dehydrogenase activity was also decreased by restraint stress. We think that radiorespirometric analysis may be useful for the evaluation of stress effect on real metabolism of ethyl alcohol in the liver.

• 公益社団法人日本薬学会の論文
• 2004-04-01

著者

• Nagase Satoru

  東北大学 医学部産婦人科

• SUZUKI Atsuko

  Department of Geriatric Medicine, Osaka University Graduate School of Medicine

• OHTAKE Yosuke

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• OHKUBO Yasuhito

  Department of Radiopharmacology, Tohoku Pharmaceutical University

• Ohtake Yosuke

  Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.

• SATO Naoko

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Sato N

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• MARUKO Akiko

  Department of Radiopharmacy, Tohoku Pharmaceutical University

• Maruko Akiko

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohuchi Yukie

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohkubo Yasuhito

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• 大窪 芳子

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Ohtake Yosuke

  Department Of Radiopharmacology Tohoku Pharmaceutical University

• Nagase Satoru

  Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine

• Sato Naoko

  Department Of Obstetrics And Gynecology Tohoku University Graduate School Of Medicine

• Sato Naoko

  Department Of Applied Chemistry School Of Engineering The University Of Tokyo And Crest Japan Scienc

• Suzuki Atsuko

  Department Of Radiopharmacy Tohoku Pharmaceutical University

• Suzuki Atsuko

  Department Of Cardiology Seirei Mikatahara Hospital

• Sato Naoaki

  Department Of Gynecology And Obstetrics Tohoku University Hospital

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