Gene Expression Profiles in Mouse Liver Cells after Exposure to Different Types of Radiation
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概要
- 論文の詳細を見る
The liver is one of the target organs of radiation-induced cancers by internal exposures. In order to elucidate radiation-induced liver cancers including Thorotrast, we present a new approach to investigate in vivo effects of internal exposure to α-particles. Adopting boron neutron capture, we separately irradiated Kupffer cells and endothelial cells in mouse liver in vivo and analyzed the changes in gene transcriptions by an oligonucleotide microarray. Differential expression was defined as more than 3-fold for up-regulation and less than 1/3 for under-regulation, compared with non-irradiated controls. Of 6,050 genes examined, 68 showed differential expression compared with non-irradiated mice. Real-time polymerase chain reaction validated the results of the microarray analysis. Exposure to α-particles and γ-rays produced different patterns of altered gene expression. Gene expression profiles revealed that the liver was in an inflammatory state characterized by up-regulation of positive acute phase protein genes, irrespective of the target cells exposed to radiation. In comparison with chemical and biological hepatotoxicants, inductions of Metallothionein 1 and Hemopexin, and suppressions of cytochrome P450s are characteristic of radiation exposure. Anti-inflammatory treatment could be helpful for the prevention and protection of radiation-induced hepatic injury.
- 日本放射線影響学会の論文
- 2008-01-15
著者
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KUWAHARA Yoshikazu
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University
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FUKUMOTO Manabu
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University
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ONO Koji
Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University
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Li Li
Department of Gynecology, The People's Hospital of Xinjiang Province, Xinjiang Medical University
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OHTAKE Yosuke
Department of Radiopharmacology, Tohoku Pharmaceutical University
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OHKUBO Yasuhito
Department of Radiopharmacology, Tohoku Pharmaceutical University
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Fukumoto Manabu
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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Kuwahara Yoshikazu
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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Ohtake Yosuke
Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.
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Fukuoka Masako
岡山大学 薬学部 衛生代謝解析学
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KASAOKA Satoshi
Faculty of Pharmacology Teikyo Univ.
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Wang Lu
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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Kasaoka Satoshi
Faculty Of Pharmaceutical Sciences Hiroshima International University
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Ono Koji
Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University
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Fukumoto Manabu
Dept. Pathol. Idac. Tohoku Univ.
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Fukumoto M
First Department Of Pathology School Of Medicine Kyoto University
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Ohuchi Yukie
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Nakagawa Hironobu
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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BABA Taisuke
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University
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ROUDKENAR Mehryar
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University
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Ohkubo Yasuhito
Department Of Radiopharmacology Tohoku Pharmaceutical University
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Fukumoto Manabu
Department Of Pathology And Biology Of Disease Faculty Of Medicine Kyoto University
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大窪 芳子
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Baba Taisuke
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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Wang Lu
Department Of Human Pathology The University Of Tokushima Graduate School
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Li Li
Guangdong Key Laboratory For Research And Development Of National Drugs Guangdong Medical College
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Roudkenar Mehryar
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University:research Center
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Li Li
Department Of Pathology Institute Of Development Aging And Cancer Tohoku University
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Li Li
Department Of Cardiology Renmin Hospital Of Gansu Province
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Li Li
Department Of Cancer Epidemiology Chinese Academy Of Medical Sciences
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