Protective Effects of Decursin and Decursinol Angelate against Amyloid β-Protein-Induced Oxidative Stress in the PC12 Cell Line : The Role of Nrf2 and Antioxidant Enzymes
スポンサーリンク
概要
- 論文の詳細を見る
The protective effects of decursin (D) and decursinol angelate (DA) purified from Angelica gigas Nakai on amyloid β-protein (Aβ)-induced neurotoxicity and the underlying mechanisms were investigated. Aβ plays a major role in the pathogenesis of Alzheimer’s disease (AD) by eliciting oxidative stress. It significantly increased cytotoxicity and lipid peroxidation, but decreased glutathione contents and antioxidant enzyme activities. All of these results were markedly reversed by pretreatment with D or DA. Nuclear transcription factor Nrf2, which regulates the expression of antioxidant enzymes, was significantly increased by D or DA pretreatment. Furthermore, D and DA suppressed Aβ aggregation. These results suggest that D and DA increase cellular resistance to Aβ-induced oxidative injury in the rat pheochromocytoma (PC12) cells, presumably through not only the induction of Nrf2 and related antioxidant enzymes, but also the anti-aggregation of Aβ. Thus D and DA have therapeutic potential in treating AD and other oxidative stress-related diseases.
- 2011-03-23
著者
-
LI Wei
Department of Hematology, Affiliated Hospital of Academy of Military Medicine Science
-
Li Li
Department of Gynecology, The People's Hospital of Xinjiang Province, Xinjiang Medical University
-
LEE Yong-Woo
Department of Smart Foods and Drugs, Graduate School, Inje University
-
KIM Yong-Ho
Department of Smart Foods and Drugs, Graduate School, Inje University
-
Kim Yong-ho
Department Of Materials Science And Engineering Hongik University
-
Jung Sang-won
Department Of Smart Foods And Drugs Graduate School Inje University
-
Li Li
Department Of Smart Foods And Drugs Graduate School Inje University
-
Kim Yong-ho
Department Of Smart Foods And Drugs Graduate School Inje University
-
Lee Yong-woo
Department Of Smart Foods And Drugs Graduate School Inje University
-
Li Wei
Department Of Clinical Laboratory Qilu Hospital Shandong University
-
Li Wei
Department Of Smart Foods And Drugs Graduate School Inje University
-
Li Wei
Department Of Chinese Material Medicine Chinese Material Medicine College Of Jilin Agricultural Univ
-
Li Li
Department Of Cardiology Renmin Hospital Of Gansu Province
-
Li Li
Department Of Cancer Epidemiology Chinese Academy Of Medical Sciences
関連論文
- Low-Dose Radiation Induces Adaptive Response in Normal Cells, but not in Tumor Cells : In vitro and in vivo Studies
- IS-80 Attributed Causes of Cancer in China : Hormone Replacement Therapy, Oral Contraceptives and Reproductive Factors(Group11 Women's Health2,International Session)
- IS-22 Study the relationship between HPV genotypes and cervical lesions of Uygur women in the south of Xinjiang(Group3 Oncology3,International Session)
- Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients
- Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis
- Amino Acids and Peptides. LI. Application of the 2-Adamantyloxycarbonyl (2-Adoc) Group to the Protection of the Hydroxyl Function of Tyrosine in Peptide Synthesis
- Reduction of Tumorigenicity by an Interferon-γ-Gene-Transduced Tumor on Another Syngeneic Tumor in a Murine Model
- Gene Expression Profiles in Mouse Liver Cells after Exposure to Different Types of Radiation
- Effects of Basic Fibroblast Growth Factor on Radiation-Induced Proliferation Inhibition and Apoptosis in Thymocytes and Splenocytes
- Expression of GLUT-1 in psoriasis and the relationship between GLUT-1 upregulation induced by hypoxia and proliferation of keratinocyte growth