A Prospective Comparison of the Epidemiological and Clinical Characteristics of Pandemic (H1N1) 2009 Influenza A Virus and Seasonal Influenza A Viruses in Guangzhou, South China in 2009
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概要
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Comparisons of the clinical characteristics of contemporaneous pandemic (H1N1) 2009 influenza A virus (A(H1N1)pdm09)- and seasonal influenza viruses-infected patients are important for both clinical management and epidemiological studies. A prospective multicenter observational study was conducted using a preestablished sentinel surveillance system in Guangzhou, China during 2009. In this study, the clinical presentations of patients with either acute respiratory infection or community-acquired pneumonia were recorded, and nasopharyngeal swab samples were collected for detection of respiratory virus strains using cell cultures or real-time reverse transcription/real-time polymerase chain reaction. Comparisons of the clinical features between A(H1N1)pdm09- and seasonal influenza viruses-infected patients were conducted accordingly. Of the 1,498 patients examined, 265 tested positive for A(H1N1)pdm09, 286 were positive for seasonal influenza A viruses, and 137 for influenza B viruses. The predominant virus was influenza B before the emergence of A(H1N1)pdm09 (epidemiological week [EW] 1–EW 21); then, predominantly non-A(H1N1)pdm09 influenza A and, later, A(H1N1)pdm09, which peaked in EW 46. Compared with the common seasonal influenza-infected patients, A(H1N1)pdm09-infected patients were younger, and had a higher proportion of these patients reported prior contact with infected individuals (P < 0.001, by χ2 test). However, few significant differences were observed in clinical symptoms and severity among any of the infections caused by the different influenza A strains. Our hospital-based network served as a useful source of information during A(H1N1)pdm09 monitoring. Viral distribution in Guangzhou was characterized by a sharp rise in A(H1N1)pdm09-infected patients in September 2009. Similar to seasonal influenza A-infected cases, A(H1N1)pdm09 cases had a very small proportion of severe cases.
著者
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Jiang Mei
Department Of Obstetrics And Gynecology Nagoya University School Of Medicine.
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Li Li
Department Of Cancer Epidemiology Chinese Academy Of Medical Sciences
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Yang Zi-feng
Macau University of Science and Technology, Faculty of Chinese Medicine
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Zhan Yang-qing
Department of Respiratory Medicine of The First Affiliated Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Chen Rong-chang
Department of Respiratory Medicine of The First Affiliated Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Zhou Rong
The First Affiliated Hospital of Guangzhou Medical College, Division of Clinical Virology of State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Wang Yu-tao
The First Affiliated Hospital of Guangzhou Medical College, Division of Clinical Virology of State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Luo Yi
Guangdong Provincial Hospital of Traditional Chinese Medicine, Emergency Department
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Li Ji-qiang
Guangdong Provincial Hospital of Traditional Chinese Medicine, Emergency Department
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Qin Sheng
The First Affiliated Hospital of Guangzhou Medical College, Division of Clinical Virology of State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Guan Wen-da
The First Affiliated Hospital of Guangzhou Medical College, Division of Clinical Virology of State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Lai Ke-fang
Department of Respiratory Medicine of The First Affiliated Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Wen Huan-lian
Department of Infectious Disease of The First Affiliated Hospital of Guangzhou Medical College
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Liang Zeng-wei
Department of Infectious Disease of The First Affiliated Hospital of Guangzhou Medical College
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Zhong Nan-shan
Department of Respiratory Medicine of The First Affiliated Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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Jiang Mei
Department of Respiratory Medicine of The First Affiliated Hospital of Guangzhou Medical College, State Key Laboratory of Respiratory Disease (Guangzhou Medical University)
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