Augmentation in Chemosensitivity of Intratumor Quiescent Cells by Combined Treatment with Nicotinamide and Mild Hyperthermia

スポンサーリンク

概要

• 論文の詳細を見る
• 1997-08-31

著者

• Takagaki Masao

  Department Of Radiology Osaka Medical College

• MASUNAGA Shin-ichiro

  Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University

• ONO Koji

  Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University

• KINASHI Yuko

  Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University

• TAKAGAKI Masao

  Radiat. Oncol. Res. Lab. Res. Reactor Inst. Kyoto Univ.

• SUZUKI Minoru

  Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University

• AKABOSHI Mitsuhiko

  Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University

• KAWAI Ken-ichi

  Radiation Life Science, Research Reactor Institute, Kyoto University

• Ono Koji

  Particle Radiation Oncology Research Center Kyoto University

• Kinashi Yuko

  Radiation Safety And Control Research Reactor Institute Kyoto University

• Miyata Shiro

  Dep. Of Neurosurgery Osaka Medical Coll.

• Kawai Kumi

  Department Of Pathology Aichi Medical University School Of Medicine

• Kawai K

  Nagoya Univ. School Of Medicine Nagoya

• Kinashi Yuko

  Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University

• Ono Koji

  Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University

• Suzuki Masao

  Heavy-ion Radiobiology Res. Group National Inst. Radiological Sciences

• Masunaga Shin-ichiro

  Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University

• Kinashi Yuko

  Kyoto Univ. Research Rcactor Institute

• Kawai K

  Research Reactor Institute Kyoto University

• Akaboshi M

  Kyoto Univ. Ohsaka Jpn

• Takahashi Masatsugu

  Department Of Radiology Osaka Medical College

関連論文

• 4.最新放射線治療とその治療成績 : 放射線治療における外科治療の役割(PS1-1 悪性グリオーマ治療の進歩,プレナリーセッション,手術再考,第30回日本脳神経外科コングレス総会)
• Phosphorylated H2AX Foci in Tumor Cells Have No Correlation with Their Radiation Sensitivities
• DNA Damage Recognition Proteins Localize along Heavy Ion Induced Tracks in the Cell Nucleus
• LOH Analyses for Biological Effects of Space Radiation : Human Cell Culture in "Kibo" of International Space Station
• 鼻腔悪性黒色腫症例に対する硼素中性子捕捉療法
• DP-070-7 切除不能上縦隔悪性神経原性腫瘍に対しホウ素中性子捕捉療法が奏効した1治験例(第108回日本外科学会定期学術集会)
• P-352 新規抗がん剤TZT-1027の細胞周期の調節および放射線増感性について(分子生物学4, 第47回日本肺癌学会総会)
• Boron neutron capture therapy for newly diagnosed glioblastoma
• Impact of the p53 Status of the Tumor Cells on the Effect of Reactor Neutron Beam Irradiation, with Emphasis on the Response of Intratumor Quiescent Cells
• Effects of p53 Status on Radiosensitivity and the Size of Hypoxic Fraction of Intratumor Total and QuiescentCell Populations
• Evaluation of the Potential of p-Boronophenylalaninol as a Boron Carrier in Boron Neutron Capture Therapy, Referring to the Effect on Intratumor Quiescent Cells
• Sensitizing Effect of the Phosphatidylinositol 3-kinase Inhibitor Wortmannin on Thermal Neutron Irradiation with or without Boron Compound
• BNCT Effect of BPA-ol, a Derivative of BPA, and Enhancement by Hyperthermia
• The Effects of Boron Neutron Capture Therapy on Liver Tumors and Normal Hepatocytes in Mice
• The Combined Effect of Electroporation and Borocaptate in Boron Neutron Capture Therapy for Murine Solid Tumors
• Changes in the Sensitivity of Intratumor Cells during Fractionated Tirapazamine Administration
• Usefulness of Tirapazamine as a Combined Agent in Chemoradiation and Thermo-chemoradiation Therapy at Mild Temperatures: Reference to the Effect on Intratumor Quiescent Cells
• Effect of Electroporation on Cell Killing by Boron Neutron Capture Therapy Using Borocaptate Sodium (^B-BSH)
• Time-course Change in Oxygenation Status of Total and Quiescent Cell Populations in Solid Tumors after γ-ray Irradiation, Tirapazamine Injection or Cisplatin Treatment
• Applicability of Combination with Tirapazamine in Boron Neutron Capture Therapy
• Effects of Boron Neutron Capture Therapy Using Borocaptate Sodium in Combination with a Tumor-selective Vasoactive Agent in Mice
• Responeses of Total and Quiescent Cell Populations in Solid Tumors to Boron and Gadolinium Neutron Capture Reaction Using Neutrons with Two Different Energy Spectra
• Physical and Biological Characteristics of the Neutron Beam from Remodeled Heavy Water Facility of Kyoto University Research Reactor
• Effects of Bioreductive Agents, Tirapazamine and Mitomycin C, on Quiescent Cell Populations in Solid Tumors, Evaluated by Micronucleus Assay
• Augmentation in Chemosensitivity of Intratumor Quiescent Cells by Combined Treatment with Nicotinamide and Mild Hyperthermia
• Determination and Drug Modification Assessed by Micronucleus Frequency Assay of Potentially Lethal Damege Repair in Quiescent Cell Populations within Murine Solid Tumors
• Boron Neutron Capture Therapy (BNCT) for Malignant Glioma using ^B-BPA
• 加速器中性子源によるホウ素中性子捕捉療法の展望 (特集 放射線治療の臨床応用)
• High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation
• Time Course and Spacial Distribution of UV Effects on Human Skin in Organ Culture
• Development of thermotolerance requires interaction between polymerase-β and heat shock proteins
• 新規抗がん剤TZT-1027の細胞周期に与える影響および放射線増感性についての検討
• 18. 新規抗癌剤TZT-1027の細胞周期への影響および放射線増感性(第84回 日本肺癌学会関西支部会,関西支部,支部活動)
• The First Life Science Experiments in ISS : Reports of "Rad Gene"-Space Radiation Effects on Human Cultured Cells-
• ホウ素中性子捕捉療法の皮膚線量低減と線量分布を改善する中性子照射技術の検討
• 中性子捕捉療法の線量評価
• 再発唾液腺腫瘍に対する新しい治療法
• トピックス講演 新たな段階に入った硼素中性子捕捉療法 (京都大学原子炉実験所第39回学術講演会 報文集)
• 硼素中性子捕捉療法新時代の到来
• 中性子捕捉療法の現状と将来
• 硼素中性子捕捉療法時の患部近傍での放射化の評価
• 頭頸部癌に対する硼素中性子捕捉療法 (京都大学原子炉実験所第42回学術講演会報文集)
• 癌放射線治療の新たなパラダイム : 硼素中性子捕捉療法(癌細胞選択的放射線治療)の現状と将来
• 放射線誘発バイスタンダー効果におけるDMSOの影響
• P075 放射線誘発バイスタンダー効果がDMSOにより抑制される機構(ポスターセッション)
• P047 X線照射された細胞での微小核形成とヒストンH2AXリン酸化フォーカス形成(ポスターセッション)
• W4-3 放射線誘発バイスタンダー効果がDMSOにより抑制される機構(ワークショップ(4) : 遺伝的不安定性と変異)
• ホウ素中性子捕捉療法(BNCT)の現状と将来の展開
• 固形腫瘍細胞特に放射線抵抗性休止期細胞の増感から見たTirapazamineの意義--腫瘍内低酸素領域の利用 (特集 第35回放射線による制癌シンポジウム--低LET放射線は生物学的手法の併用によって高LET放射線を超えられるか) -- (低酸素細胞の克服による増感)
• バイスタンダー効果の機構解析と今後の展望
• 再発頭頸部悪性腫瘍に対するホウ素中性子捕捉療法
• 頭頸部悪性腫瘍に対するBNCT後の経過と今後の展開 (平成14年度専門研究会報告書「中性子捕捉療法システムの高度化」)
• Recent Advances in the Biology of Heavy-Ion Cancer Therapy
• ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating
• γ-ray Irradiation Enhanced Boron-10 Compound Accumulation in Murine Tumors
• A Simple and Rapid Method for Measurement of ^B-para-Boronophenylalanine in the Blood for Boron Neutron Capture Therapy Using Fluorescence Spectrophotometry
• Boron Neutron Capture Therapy for Newly Diagnosed Glioblastoma
• Evaluation of Hypoxia-specific Cytotoxic Bioreductive Agent-sodium Borocaptate-^B Conjugates as ^B-carriers in Boron Neutron Capture Therapy
• S-4-4 From Regionally Selective Radiotherapy to Cellular Selective Radiotherapy(Aiming Further Development of Radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 熱外中性子および集積機序の異なる二種類の硼素化合物を同時併用した悪性脳腫瘍に対する新規硼素中性子捕捉療法
• Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors : its Independency of p53 Status
• 癌のホウ素中性子捕捉療法--捕獲反応α粒子による細胞選択的放射線治療
• Potentially Lethal Damage Repair by Total and Quiescent Tumor Cells Following Various DNA-damaging Treatments
• Enhancement of Cisplatin Sensitivity of Quiescent Cells in Solid Tumors by Combined Treatment with Tirapazamine and Low-Temperature Hyperthermia
• Resistance to ^Pt-radiolabeled cis-Diaminedichloroplatinum (II) of SHOK Cells Transfected with Various Oncogenes
• Cell-killing Efficiency and Number of Platinum Atoms Binding to DNA, RNA and Protein Molecules of HeLa Cells Treated with Combinations of trans-Diaminedichloroplatinum (II) and Hyperthermia
• Relationship between Cell-killing Efficiency and Number of Platinum Atoms Binding to DNA, RNA, and Protein Molecules in HeLa Cells Treated with cis -Diamine (glycolato) platinum (II)
• 中性子捕捉療法のための熱中性子リアルタイムモニタの開発
• ホウ素中性子捕獲反応の利用が拓く基礎放射線腫瘍学研究の新局面 (京都大学原子炉実験所第45回学術講演会報文集)
• 悪性脳腫瘍に対する放射線療法 : 標準治療と最先端(悪性グリオーマ-機能温存と予後 (標準化治療法作成を目指して), PA-1 悪性脳腫瘍-標準化治療と治療抵抗例への挑戦, 第25回 日本脳神経外科コングレス総会)
• 適用拡大を目指した加速器ベースNCT照射システムの検討案
• SOF検出器によるBNCT治療中のリアルタイム熱中性子束評価 (平成14年度専門研究会報告書「中性子捕捉療法システムの高度化」)
• 京大炉(KUR)におけるこれまでの医療照射のまとめ (平成14年度専門研究会報告書「中性子捕捉療法システムの高度化」)
• BNCT用線量計画システム「SERA」の概要とKURにおける適用 (第37回京都大学原子炉実験所学術講演会)
• Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations
• Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
• Evaluation of Micronucleus Induction in Lymphocytes of Patients Following Boron-Neutron-Capture-Therapy : A Comparison with Thyroid Cancer Patients treated with radioiodine
• 84 Effects of Mild Temperature Hyperthermia and p53 Status of Tumor Cells on the Size of Hypoxic Cell Fractions in Solid Tumors(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Effects of p53 Status and Wortmannin Treatment on Potentially Lethal Damage Repair, with Emphasis on the Response of Intratumor Quiescent Cells
• Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors : its independence of p53 status
• Development of Selective Irradiation Method to Blood Vessel
• Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo
• Local hyperthermia combined with external irradiation for regional recurrent breast carcinoma
• The Effects of Irradiation of Low Dose and Low Dose Rate on p53-centered Signal Transduction in Human Glioblastoma Cells (A-172)
• A role of poly (ADP-Ribose) lation in Radiation-induced Waf1 Induction in Human Glioblastoma Cells.
• Hyperthermic Enhancement of Tumor Growth Inhibition by Carbon-ions and X-rays in Transplantable Esophageal Cancer
• p53- Dependent Hyperthermic Enhancement of Cell Killing by Radiations in Human Glioblastoma Cells (A-172/wtp53) Transfected with mp53 Gene.
• Effects of an Inhibitor of Poly(ADP-Ribose) Polymerase, 3-Aminobenzamide, on γ-Induced WAF1 Gene Expression in Human Glioblastoma Cells.
• p53-Dependence of Heat- or γ-Ray-Induced Signal Transduction for WAF1 Expression of Human Glioblastoma Cells (A-172/wtp53) Transfected with mp53 Gene.
• Patients' subjective evaluation of early and late sequelae in patients with breast cancer irradiated with short fractionation for breast conservation therapy : comparison with conventional fractionation
• Synthesis and Evaluation of the Compounds Containing ^B and ^F Atoms as Boron Carrier and Imaging Agent
• Study of the Fluorine- and Boron-10 Containing Compounds toward MRI and BNCT
• Gene Expression Profiles in Mouse Liver Cells after Exposure to Different Types of Radiation
• Stereotactic radiosurgery (SRS) for multiple metastatic brain tumors : effects of the number of target tumors on exposure dose in normal brain tissues
• "Probable" and "definitive" diagnosis of a formidable disease : Creutzfeldt-Jacob disease
• Significance of the Response of Quiescent Cell Populations within Solid Tumors in Cancer Therapy
• Increase in Tumor Oxygenation and Potentiation of Radiation Effects Using Pentoxifylline, Vinpocetine and Ticlopidine Hydrochloride
• Gadolinium neutron capture therapy for malignant brain tumors
• Evaluation of tumor response following single irradiation of clinical relevant dose - colony assay -
• Stereotactic radiosurgery (SRS) for multiple metastatic brain tumors: effects of the number of target tumors on exposure dose in normal brain tissues (ナノ・サブマイクロ技術を用いた模擬/人工生体組織の創製と新診断・治療法の開発プロジェクト)

もっと見る 閉じる

スポンサーリンク