"Probable" and "definitive" diagnosis of a formidable disease : Creutzfeldt-Jacob disease
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概要
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A 75-year-old female with rapidly progressive dementia, pyramidal and extrapyramidal signs, myoclonus, and mutism received a diagnosis of probable sporadic Creutzfeldt-Jakob disease (sCJD) after eliminating other possible candidates, such as normal pressure hydrocephalus (NPH), some form of encephalopathy, and so on. However, postmortem brain biopsy revealed the case to be non-CJD. Facing the triad of progressive dementia, myoclonus, and pyramidal/extrapyramidal features, Alzheimer's disease (AD) should be retrospectively considered if the disease course is long and dementia with Lewy bodies (DLB) is the differential diagnosis if Parkinsonism is present. Findings on electroencephalogram (EEG) or in cerebrospinal fluid (CSF) typical of CJD do not exclude AD or DLB.
著者
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Takagaki Masao
Department Of Radiology Osaka Medical College
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KAZUI Hiroaki
Department of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine
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Kazui Hiroaki
Department Of Psychiatry Graduate School Of Medicine Osaka University
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Kazui Hiroaki
Department Of Clinical Neurosciences Hyogo Institute For Aging Brain And Cognitive Disorders
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Takagaki Masao
Department Of Neurosurgery Aino Junior College Hospital
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Takagaki Masao
Department Of Nursing Aino Gakuin College
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SUMIOKA Mayumi
C6 Ward, Aino Hospital
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Sumioka Mayumi
C6 Ward Aino Hospital
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