A Simple and Rapid Method for Measurement of ^<10>B-para-Boronophenylalanine in the Blood for Boron Neutron Capture Therapy Using Fluorescence Spectrophotometry
スポンサーリンク
概要
- 論文の詳細を見る
Background and Purpose; 10B deriving from 10B-para-boronophenylalanine (BPA) and 10B-borocaptate sodium (BSH) have been detected in blood samples of patients undergoing boron neutron capture therapy (BNCT) using prompt gamma ray spectrometer or Inductively Coupled Plasma (ICP) method, respectively. However, the concentration of each compound cannot be ascertained because boron atoms in both molecules are the target in these assays. Here, we propose a simple and rapid method to measure only BPA by detecting fluorescence based on the characteristics of phenylalanine. Material and Methods; 10B concentrations of blood samples from human or mice were estimated by the fluorescence intensities at 275 nm of a BPA excited by light of wavelength 257 nm using a fluorescence spectrophotometer. Results; The relationship between fluorescence to increased BPA concentration showed a positive linear correlation. Moreover, we established an adequate condition for BPA measurement in blood samples containing BPA, and the estimated 10B concentrations of blood samples derived from BPA treated mice were similar between the values obtained by our method and those by ICP method. Conclusion; This new assay will be useful to estimate BPA concentration in blood samples obtained from patients undergoing BNCT especially in a combination use of BSH and BPA.
- 日本放射線影響学会の論文
- 2009-07-16
著者
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小野 公二
京都大学原子炉実験所 粒子線腫瘍学研究センター
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増永 慎一郎
京都大学大学院医学研究科放射線医学講座腫瘍放射線科学
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Ohnishi Takeo
奈良県立医科大学 生物学
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Suzuki Minoru
Particle Radiation Oncology Research Center Kyoto University
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MARUHASHI Akira
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University
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ONO Koji
Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University
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Suzuki M
Particle Radiation Oncology Research Center Kyoto University
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木梨 友子
京都大学原子炉実験所附属粒子線腫瘍学研究センター
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Sakurai Yoshinori
Research Reactor Institute Kyoto University
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Sakurai Yoshinori
京都大学原子炉実験所
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Maruhashi Akira
Research Reactor Institute Kyoto University
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Liu Yong
Particle Radiation Oncology Research Center Kyoto University
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Liu Yong
Particle Radiation Oncology Research Center Research Reactor Institute Kyoto University
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Ono Koji
Particle Radiation Oncology Research Center Kyoto University
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Kinashi Yuko
Radiation Safety And Control Research Reactor Institute Kyoto University
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KASHINO Genro
Particle Radiation Oncology Research Centre, Research Reactor Institute, Kyoto University
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FUKUTANI Satoshi
Laboratory of Radioactive Waste Management, Research Reactor Institute, Kyoto University
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NAGATA Kenji
Particle Radiation Oncology Research Centre, Research Reactor Institute, Kyoto University
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MASUNAGA Shin-Ichiro
Particle Radiation Oncology Research Centre, Research Reactor Institute, Kyoto University
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TANAKA Hiroki
Laboratory of Radiation Medical Physics, Research Reactor Institute, Kyoto University
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SAKURAI Yoshinori
Laboratory of Radiation Medical Physics, Research Reactor Institute, Kyoto University
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KINASHI Yuko
Laboratory of Radiation Safety and Control, Research Reactor Institute, Kyoto University
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FUJII Noriko
Laboratory of Radiation Biochemistry and Biological function, Research Reactor Institute, Kyoto Univ
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Masunaga Shin-ichiro
Particle Radiation Oncology Research Center Kyoto University
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OKAICHI Kumio
Nara Med. Univ.
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Miyata Shiro
Dep. Of Neurosurgery Osaka Medical Coll.
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Nagata Kenji
Particle Radiation Oncology Research Centre Research Reactor Institute Kyoto University
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Mori Sao
Lab. Radiat. Life Sci. Schi. Pharm. Sci. Nagasaki Univ.
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Fujii Noriko
Laboratory Of Radiation Biochemistry And Biological Function Research Reactor Institute Kyoto Univer
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Omori Katsunori
Institute Of Space And Astronautical Science Japan Aerospace Exploration Agency (jaxa)
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Omori Katsunori
Department Of Space Biology And Microgravity Sciences And Iss Science Project Office Institute Of Sp
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Kashino Genro
Particle Radiation Oncology Research Center Kyoto University
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Liu Yong
Particle Radiation Oncology Res. Center Res. Reactor Inst. Kyoto Univ.
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Kinashi Yuko
Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University
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NAKANO KAZUSHIRO
The Institute of Physical and Chemical Research
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Kashino Genro
Particle Radiation Oncology Research Centre Research Reactor Institute Kyoto University
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Suzuki Masao
National Inst. Radiological Sci. Chiba Jpn
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Suzuki Masao
Heavy-ion Radiobiology Res. Group National Inst. Radiological Sciences
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Sakurai Y
Research Reactor Institute Kyoto University
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Ono Koji
京都大学原子炉実験所附属粒子線腫瘍学研究センター
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Ono K
Radiation Oncology Research Laboratory Research Reactor Institute Kyoto University
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Fukutani Satoshi
Laboratory Of Radioactive Waste Management Research Reactor Institute Kyoto University
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Kashino Genro
京都大学原子炉実験所附属粒子線腫瘍学研究センター
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Kinashi Yuko
Kyoto Univ. Research Rcactor Institute
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Kashino Genro
Particle Radiation Oncology Research Center Kyoto University Research Reactor Institute
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増永 慎一郎
Particle Radiation Oncology Res. Center Res. Reactor Inst. Kyoto Univ.
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Ohnishi Ken
Dept. Biology Nara Med. Univ.
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Matsumura Akira
Research Reactor Institute Kyoto University
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Kashino Genrou
Particle Radiation Oncology Research Centre Research Reactor Institute Kyoto University
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Tanaka Hiroaki
Radiation Medical Physics Research Reactor Institute Kyoto University
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Suzuki Minoru
Particle Oncology Research Center Research Reactor Institute Kyoto University
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Tanaka Hiroki
Laboratory Of Forest Hydrology Division Of Environmental Science And Technology Graduate School Of A
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Ogura Koichi
College Of Industrial Technology Nihon University
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Kobayashi Yasuhiko
Advanced Science Research Center Japan Atomic Energy Research Institute
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