The Effects of Several Vasopressin Receptor Antagonists on Normal Intraocular Pressure and the Intraocular Distribution of Vasopressin Receptor Subtypes
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概要
- 論文の詳細を見る
The aim of the present paper is to study the relation hetwcen vasopressin antagonism and the regulation of intraocular pressure (IOP). From the studics on the effect of several vasopressin receptor antagonists, VP-343, OPC-21268, YM087, OPC-31260 and SR121463, on normal IOP and the effect of VP-343 on pupil diameter in rabbit, it was shown that some vasopressin antagonists decreased normal IOP and VP-343 had no influence on pupil diameter. A vasoprcssin receptor mapping study in normal cynomolgus monkey eye revealed a high density binding site for a [H^3]vasopressin V_1 antagonist in the region of iris. These findings suggest that a vasopressin an- tagonist should decrease normal IOP without miosis and that vasopressin V_1 receptors are present in iris.
- 2002-02-01
著者
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OHTAKE Yosuke
Department of Radiopharmacology, Tohoku Pharmaceutical University
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Ohtake Yosuke
Dep. Of Radiopharmacology Tohoku Pharmaceutical Univ.
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Naito Akira
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Koike Katsuo
東京薬科大学 内分泌分子薬理学
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Koike K
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Naito A
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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KURASAWA Takashi
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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OHTAKE Yasuhiro
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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TOYODA Yoshihiro
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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EZURE Yohji
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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KOlKE Katsuo
Toho University School of Pharmaceutical Sciences
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KOIKE Katsuo
Toho University School of Pharmaceutical Sciences
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Koike K
Toho Univ. Chiba Jpn
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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大窪 芳子
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Ezure Yohji
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Ohtake Yasuhiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Kurasawa Takashi
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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