Effect of humulus lupulus on Gastric Secretion in a Rat Pylorus-Ligated Model(Pharmacology)
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概要
- 論文の詳細を見る
In this study, we investigated the pharmacological effect of humulus lupulus (hops) on gastric juice volume and acidity using a rat pylorus-ligated model. In an intraorally administered experiment, hops clearly increased gastric juice volume without affecting acidity. On the other hand, hops had no influence on gastric juice volume when it was intragastrically administered. A cholinergic agonist, carbachol, increased gastric juice volume without affecting acidity, whereas histamine increased gastric juice volume and acidity. The increase of gastric juice volume induced by carbachol was completely inhibited by atropine. On the other hand, atropine did not inhibit the increase in gastric juice volume induced by histamine. The increase in gastric juice volume induced by hops was completely inhibited by atropine. These results suggested that the increase in gastric juice volume induced by intraorally administered hops could be mediated by the cholinergic nervous system.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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Naito Akira
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Naito A
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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KURASAWA Takashi
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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TOYODA Yoshihiro
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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NOTSU Yoshitada
Sagami Research Laboratories, Wakamoto Pharmaceutical Company, Ltd.
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Notsu Y
Fujisawa Pharmaceutical Co. Ltd. Ibaraki Jpn
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Notsu Yoshitada
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Notsu Yoshitada
Sagami Research Laboratories Wakamoto Pharmaceutical Company Ltd.
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CHIKARAISHI Yuichi
Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd.
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kurasawa Takashi
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Chikaraishi Yuichi
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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