Involvement of the Na^+/Ca^<2+> Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400
スポンサーリンク
概要
- 論文の詳細を見る
We examined the involvement of the Na+/Ca2+ exchanger in the automaticity of the pulmonary vein myocardium with a specific inhibitor, SEA0400. Action potentials were recorded from the myocardial layer of isolated guinea-pig pulmonary vein preparations, and Ca2+ transients were recorded from the cardiomyocytes. Spontaneous electrical activity was observed in 17.7% of the preparations, which was inhibited by either SEA0400 or ryanodine. In quiescent preparations, ouabain induced electrical activity and spontaneous Ca2+ transients, which were inhibited by SEA0400, as well as ryanodine. These results provide pharmacological evidence that the Na+/Ca2+ exchanger underlies the automaticity of the pulmonary vein myocardium.
- 社団法人 日本薬理学会の論文
- 2009-05-20
著者
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Shimada Hideaki
Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu Universi
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Shimada Hideaki
千葉大学 医学研究院先端応用外科学
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Shimada H
Department Of Frontier Surgery Graduate School Of Medicine Chiba University
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Takeda Kentaro
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Shiina Hiroyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimada Hideaki
Department Of Gastroenterological Surgery Chiba Cancer Center
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Sugimoto Takahiko
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Takeda Kiyoshi
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimada H
Kumamoto Univ. Kumamoto
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Shimada Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Science
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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NAGAHARU Midori
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Nagaharu Midori
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Shimada Hideaki
Department Of Frontier Surgery Chiba University Graduate School Of Medicine
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Shimada Hideaki
Department Of Academic Surgery Graduate School Of Medicine Chiba University
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Suzuki Takuo
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Sakurai Haruna
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sashiyama Hiroshi
千葉大学 医学研究院先端応用外科学
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Takeda Kiyoshi
Department Of Microbiology And Immunology Graduate School Of Medicine Osaka University
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Shimada Hideaki
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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Takeda Kiyoshi
Department Of Anesthesia Osaka National Hospital
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Tsuneoka Yayoi
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Takeda Kiyoshi
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Sugimoto Takahiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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