MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats
スポンサーリンク
概要
- 論文の詳細を見る
MaxiK channel, the large-conductance Ca^<2+>-sensitive K^+ channel, facilitates a negative feedback mechanism to oppose excitation and contraction in various types of smooth muscles including urinary bladder smooth muscle (UBSM). In this study, we investigated how the contribution of MaxiK channel to the regulation of basal UBSM mechanical activity is altered in streptozotocin-induced diabetic rats. Although the urinary bladder preparations from both control and diabetic rats were almost quiescent in their basal mechanical activities, they generated spontaneous rhythmic contractions in response to a MaxiK channel blocker, iberiotoxin (IbTx). The effect of IbTx on the mechanical activity was significantly greater in diabetic rat than in control animal. Similarly, the basal mechanical activity was increased with apamin, an inhibitor for some types of small conductance Ca^<2+>-sensitive K^+ channels, and this effect was more pronounced for diabetic rat. However, in both control and diabetic animals, IbTx action was stronger than that of apamin. Diabetes also enhanced the responses to BayK 8644, an L-type Ca^<2+> channel agonist. The extent of this enhancement in diabetic bladder vs. control was, however, almost the same as that attained with IbTx. Expression levels for MaxiK channel as well as apamin-sensitive K^+ channels and L-type Ca^<2+> channel were not altered by diabetes, when determined as their corresponding mRNA levels. These results indicate that diabetes can potentially increase the basal UBSM mechanical activity. However, in diabetic UBSM, the main negative-feedback system triggered by MaxiK channel is still preserved enough to counteract the possible enhancement of this smooth muscle mechanical activity.
- 日本平滑筋学会の論文
著者
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Sakamoto Kenji
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Sakamoto K
National Inst. Materials Sci. Ibaraki Jpn
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Sakamoto K
Laboratory Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences The University
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Kubota Yuko
Department Of Bioscience Fukui Prefectural University
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Kubota Yuko
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Koike Katsuo
東京薬科大学 内分泌分子薬理学
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Koike K
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Nakahara Tsutomu
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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MITANI Akiko
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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MARUKO Takeshi
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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KOIKE Katsuo
Toho University School of Pharmaceutical Sciences
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Koike K
Toho Univ. Chiba Jpn
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Sakamoto Kenji
Research Institute Of Marine Bioresources Fukuyama University
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Maruko Takeshi
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Ishii Kunio
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Mitani Akiko
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Nakahara Tsutomu
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Nakahara Tsutomu
Department Of Developmental Physiology Institute For Comprehensive Medical Sciences Fujita-gakuen Un
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sakamoto Kenji
Department Of Advanced Material Science Faculty Of Engineering Kagawa University
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Sakamoto Kenji
Laboratory Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences The University
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Tanaka Yoshio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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