Vasodilator Effects of Flunarizine on Retinal Blood Vessels in Anesthetized Rats
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概要
- 論文の詳細を見る
The aim of this study was to investigate the effects of intravenous administration of flunarizine on the diameter of retinal blood vessels and blood pressure in anesthetized rats and to compare the effects of this antagonist with those of nicardipine and nifedipine. Retinal vascular images were captured with a fundus camera system for small animals and the diameter of retinal blood vessels contained in the images was measured using image-processing softwares on a personal computer. Blood pressure was continuously measured. Flunarizine [1—30 μg/kg, intravenously (i.v.)] dose-dependently increased the diameter of retinal blood vessels without significantly changing systemic blood pressure. Nicardipine (1—30 μg/kg, i.v.) increased the retinal blood vessel diameter but decreased blood pressure in a dose-dependent manner. Nifedipine (10—100 μg/kg, i.v.) failed to dilate the retinal blood vessels, although it produced comparable depressor responses as those to nicardipine. These results suggest that flunarizine selectively acts on the retinal blood vessels rather than on the peripheral resistance vessels. Flunarizine could therefore be considered as a candidate for therapeutic drugs to treat diseases associated with disorders of retinal circulation without severe cardiovascular side-effects.
- 日本薬学会の論文
著者
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Sakamoto Kenji
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Sakamoto K
National Inst. Materials Sci. Ibaraki Jpn
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MORI ASAMI
Department of Pediatrics, Shiga University Medical Science
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NOGUCHI Masahiro
Department of Radiology, Sakura Hospital
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Nakahara Tsutomu
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Sakamoto Kenji
Research Institute Of Marine Bioresources Fukuyama University
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Mori Asami
Department Of Pediatrics Shiga University Medical Science
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Nakahara Tsutomu
Department Of Developmental Physiology Institute For Comprehensive Medical Sciences Fujita-gakuen Un
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Sakamoto Kenji
Department Of Advanced Material Science Faculty Of Engineering Kagawa University
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Noguchi Masahiro
Department Of Industrial Chemistry Faculty Of Engineering Ibaraki University
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Sakamoto Kenji
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Mori Asami
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Ishii Kunio
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Noguchi Masahiro
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Noguchi Masahiro
Department of Chemical Engineering, Kobe University
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