Rat Gastric Mucous Gel Layer Contains Sialomucin Not Produced by the Stomach

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概要

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• The sialylated mucus components of the normal gastric mucosa and mucous gel layer of rats were studied by using various histochemical staining methods including Maackia amurensis II (MAL-II) and Sambucus nigra (SNA) lectins, alcian blue (AB) pH 2.5 - periodic acid Schiff (PAS) and high iron diamine (HID) - AB pH 2.5. The acidic and neutral mucins characterized by the AB-PAS staining were abundantly present in the mucous gel layer as well as in the gastric mucosa. The sialomucin characterized by HID-AB was barely found in either the mucous gel layer or the mucosa. The sialomucin positive to MAL-II and SNA, which react with the N-acetyl neuraminic acid residue linked to galactose via an α-linkage, was moderately detected only in the mucous gel layer, but not in the entire mucosal layer. Furthermore, in animals given surgery to form an esophageal fistula through which saliva was excluded or in animals subjected to salivectomy, the mucous gel layer stained with MAL-II and SNA lectins was markedly decreased. These results indicate that a part of the sialomucin containing-mucous gel layer covering normal rat gastric mucosa originates from the saliva and that MAL-II and SNA lectins are useful for detecting this specific sialomucin.

• 社団法人 日本薬理学会の論文

著者

• Ishihara Kazuhiko

  Department of Regulation Biochemistry, Kitasato University School of Medicine

• Harima S

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Harima Shoichi

  京都薬科大学

• Harima Shoichi

  Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U

• Shimada Hideyo

  Division Of Pathophysiology School Of Pharmaceutical Sciences Kitasato University

• Shimada Hideyo

  Division Of Pathophysiology Center For Clinical Pharmacy And Clinical Sciences School Of Pharmaceuti

• Ishii K

  Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders

• Ishii Kunio

  Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University

• HOTTA Kyoko

  Department of Biochemistry, Kitasato University School of Medicine

• Ishii Kazunari

  Division Of Imaging Research Hyogo Institute For Aging Brain And Cognitive Disorders

• Hotta Kyoko

  Department Of Biochemistry Kitasato University School Of Medicine

• Hotta K

  Department Of Biochemistry And Medicine School Of Medicine And Nursing Kitasato University

• Hotta Kyoko

  Biochemistry School Of Medicine Kitasato University

• KODAIRA Hisamasa

  Department of Molecular Pharmacology School of Pharmaceutical Sciences, Kitasato University

• KAGOSHIMA Masatoyo

  Department of Molecular Pharmacology School of Pharmaceutical Sciences, Kitasato University

• Ishihara Kazuhiko

  Department Of Biochemistry Kitasato University Graduate School Of Medical Sciences

• Ishii Kunio

  Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences

• Kodaira Hisamasa

  Department Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato University

• Kagoshima Masatoyo

  Department Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato University

• HOTTA Kyoko

  Department of Biochemistry and Internal Medicine, Kitasato University School of Medicine

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