Medicinal Flowers. II. Inhibitors of Nitric Oxide Production and Absolute Stereostructurs of Five New Germacrane-Type Sesquiterpenes, Kikkanols D, D Monoacetate, E, F, and F Monoacetate from the Flowers of Chrysanthemum indicum L.
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract and ethyl acetate-soluble portion from the flowers of Chrysanthemum indicum L., Chrysanthemi Indici Flos, were found to show inhibitory activity against nitric oxide (NO) production in lipopolysaccharide-activated macrophages. Five new germacrane-type sesquiterpenes, kikkanols D, D monoacetate, E, F, and F monoacetate, were isolated from the ethyl acetate-soluble portion. Their absolute stereostructuers were elucidated on the basis of chemical and physicochemical evidence, which included application of the modified Mosher's method. The effects of fifteen principal components from the ethyl acetate-soluble portion of this medicinal flower against NO production were examined and, among them, a cetylenic compounds and flavonoids were found to show potent inhibitory activity.
- 社団法人日本薬学会の論文
- 2000-05-01
著者
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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TOGUCHIDA Iwao
Kyoto Pharmaceutical University
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Shimada Hideyo
Division Of Pathophysiology School Of Pharmaceutical Sciences Kitasato University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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