The Effects of Interleukin (IL)-4 and IL-10 on Macrophage Growth-Stimulating Activities of Oxidized Low Density Lipoprotein (LDL), Acetylated LDL and Macrophage Colony-Stimulating Factor : The activity of Oxidized LDL Is Refractory to the Inhibitory Cytok
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概要
- 論文の詳細を見る
We have previously reported that ligands of scavenger receptor such as acetylated low density lipoprotein (acetyl-LDL) and oxidized LDL induced growth of peripheral macrophages in vitro. This suggests the possibility that in addition to foam cell formation, modified or oxidized LDLs induce macrophage proliferation in atherosclerotic lesions. To learn further the physiological regulation of macrophage growth, we comparatively examined the effect of interleukin (IL)-4 and IL-10 which have been reported to be suppressive to various macrophage functions on macrophage growth-stimulating activities of the acetyl-LDL, oxidized LDL and macrophage colonystimulating factor (M-CSF). An in vitro study showed that the activity of M-CSF-containing L-cell-conditioned medium was the most sensitive to the suppressive effects of these cytokines. The growth-inducing activity of acetyl-LDL was significantly inhibited by both IL-4 and IL-10. On the other hand, the activity of oxidized LDL was not attenuated by IL-4 or IL-10. These data indicate that macrophage growth-stimulating activity of oxidized LDL, in contrast to that of M-CSF or acetyl-LDL, is refractory to these suppressive cytokines. Oxidized LDL may act as a potent macrophage growth-stimulating factor in atherosclerotic or other inflammatory sites, even when these cytokines are produced by inflammatory and immunological reactions in situ.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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Sawa T
Institute Of Microbial Chemistry
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Horiuchi Seikoh
Department of Biochemistry, Kumamoto University School of Medicine
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Horiuchi S
Department Of Biochemistry Kumamoto University School Of Medicine
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Horiuchi Seikoh
Department Of Medical Biochemistry Graduate School Of Medical And Pharmaceutical Sciences Kumamoto U
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Horiuchi Seikoh
帝京大学 薬
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Yamazaki M
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Yamazaki M
Teikyo Univ. Kanagawa Jpn
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Yamazaki Masatoshi
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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SASAKI Toshinori
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko
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YUI Satoru
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko
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Horiuchi Seikoh
Department Of Medical Biochemistry Graduate School Of Medical Sciences Kumamoto University
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Horiuchi Seikoh
Department Of Biochemistry Kumamoto University
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Yui S
Teikyo Univ. Kangawa Jpn
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Yui Satoru
Faculty Of Pharmaceutical Sciences Teikyo University
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Yamazaki Masatoshi
Faculty Of Pharmaceutical Science Teikyo University
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Yamazaki Masatoshi
Faculty Of Internal Arts And Science Yamagata University
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Yui Satoru
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Horiuchi Seikoh
Department Of Medical Biochemistry Graduate School Of Medical And Pharmaceutical Sciences Kumamoto U
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