Biosynthesis of Neothramycin
スポンサーリンク
概要
- 論文の詳細を見る
Neothramycins A and B, antitumor antibiotics produced by Sterptomyces No. MC916C4 are biosynthesized from tryptophan, methionine and proline. The anthranilate moiety of neothramycins is derived from tryptophan through the kynurenine pathway, similar to that in tomaymycin biosynthesis. The methoxy carbon at C-12 is derived from the S-methyl group of L-methionine, The pyrrolidine ring and the C-11 carbon are derived from an intact L-proline skeleton. The proline incorporation which has been confirmed by the ^<13>C NMR spectra of [11^<_13>C] butylneothramycin A is a new finging in the biosynthesis of 1,4-benzodiazepine antibiotics.
- 社団法人日本生物工学会の論文
- 1978-08-25
著者
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Sawa T
Institute Of Microbial Chemistry
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TAKEUCHI Tomio
Institute of Microbial Chemistry
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Kondo S
Institute Of Microbial Chemistry
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KONDO Shinichi
Institute of Microbial chemistry
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SAWA Tsutomu
Institute of Microbial Chemistry
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MIYAMOTO MASASHI
Institute of Microbial Chemistry
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UMEZAWA HAMAO
Institute of Microbial Chemistry
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Shimokawa Takashi
国立がんセンター
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Shimokawa Takashi
Div. Radiat. Biol. &biodosimet. Natl. Inst. Radiol. Sci.:toho Univ. Graduate Sch. Of Biomolecula
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Shimokawa Takashi
Natl. Inst. Radiol. Sci.
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Shimokawa Takushi
Biochemistry Division National Cancer Center Research Institute
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Takeuchi Tomio
Institute For Chemotherapy M.c.r.f.
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Kondo Shinichi
Nimura Genetic Solutions Co. Ltd.
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Kondo Shinichi
Nimura Genetic Solutions
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Umezawa Hamao
Institute of Bioorganic Chemistry
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