Antihypertensive and Natriuretic Effects of Less-Sodium Soy Sauce Containing γ-Aminobutyric Acid in Spontaneously Hypertensive Rats

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概要

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• We investigated the mechanism of the antihypertensive effect of less-sodium soy sauce containing γ-aminobutyric acid (GABA) in spontaneously hypertensive rats (SHRs). When SHRs were given a diet with less-sodium soy sauce containing GABA (GABA-rich soy sauce group) for 6 weeks, the systolic blood pressure decreased as compared with that in rats fed diets with less-sodium soy sauce or a solution of salt. Renal sympathetic nerve activity (RSNA) and positive Na balance were reduced, and the urinary Na excretion tended to increase in the GABA-rich soy sauce group. Vascular hypertrophy of the thoracic aorta and the coronary and renal interlobular arteries tended to reduce in the GABA-rich soy sauce group. These results suggest that inhibition of Na retention by natriuresis, as a result of inhibition of RSNA by the GABA in the soy sauce contributed to the antihypertensive effect of GABA in the SHRs. Intake of less-sodium soy sauce containing GABA might help to reduce overall cardiovascular risk.

• 社団法人 日本農芸化学会の論文
• 2007-01-23

著者

• Sakai Takafumi

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Takahashi S

  Cancer Prevention Basic Research Project National Cancer Center Research Institute

• Sawa T

  Institute Of Microbial Chemistry

• Sakai T

  Kyoto Univ. Kyoto Jpn

• YAMAKOSHI Jun

  Research and Development Division, Kikkoman Corporation

• OBATA Akio

  Research and Development Division, Kikkoman Corporation

• SAITO Makoto

  Research and Development Division, Kikkoman Corporation

• MATSUYAMA Asahi

  Research and Development Division, Kikkoman Corporation

• KIKUCHI Mamoru

  Research and Development Division, Kikkoman Corporation

• Fukuda Satoshi

  Research and Development Division, Kikkoman Corporation

• Satoh Takuya

  Research and Development Division, Kikkoman Corporation

• TSUJI Ryouhei

  Research and Development Division, Kikkoman Corporation

• KAWASAKI Terukazu

  Center for Health and Sports Science, Kyushu Sangyo University

• Saito Makoto

  Research And Development Division Kikkoman Corporation

• TSUJI Ryohei

  Research and Development Division, Kikkoman Corporation

• Kikuchi Masanori

  Department Of Food Production And Utility Development Graduate School Of Dairy Science Research Raku

• Obata A

  Kikkoman Corp. Chiba Jpn

• Obata Akio

  Research & Development Division Kikkoman Corporation

• Tsuji Ryouhei

  Res. And Dev. Div. Kikkoman Corp.

• Kikuchi M

  Kikkoman Corp. Chiba Jpn

• Yamakoshi Jun

  Research And Development Division Kikkoman Corporation

• Kikuchi Mamoru

  Res. And Dev. Div. Kikkoman Corp.

• Kikuchi Mamoru

  Research & Development Division Kikkoman Corporation

• Shimokawa Takashi

  Natl. Inst. Radiol. Sci.

• Kikuchi M

  Res. And Dev. Div. Kikkoman Corp.

• Fukuda Satoshi

  Research And Development Division Kikkoman Corporation

• Saito M

  Research And Development Division Kikkoman Corporation

• Matsuyama Asahi

  Research And Development Division Kikkoman Corporation

• Tsuji Ryouhei

  Research And Development Division Kikkoman Corporation

• Yamakoshi J

  Research And Development Division Kikkoman Corporation

• Kawasaki Terukazu

  Center For Health And Sports Science Kyushu Sangyo University

• Tamai Susumu

  Cancer Prevention Division National Cancer Center Research Institute

• Sugimura Takashi

  Carcinogenesis Division National Cancer Center Research Institute

• Saito Makoto

  Research & Development Division Kikkoman Corporation

• Kawasaki Terukazu

  Center For Health And Sports Science Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu Sangyo University

• Sasaki Takayuki

  Institute Of Plant Science And Resources Okayama University

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