Antioxidative Activities of 4-Hydroxy-3 (2H)-furanones and Their Anti-cataract Effect on Spontaneous Cataract Rat (ICR/f)

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概要

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• We determined the anti-cataract effects and antioxidative activities of four 4-hydroxy-3 (2H)-furanones. These four furanones showed similar antioxidative activities in the ferric ion reduction model. 4-Hydroxy-2,5-dimethyl-3 (2H)-furanone (HDMF) and 2 (or 5)-ethyl-4-hydroxy-5 (or 2)-methyl-3 (2H)-furanone (EHMF) exhibited a higher suppression effect on lipid peroxidation in human plasma than the other furanones did. The effects of hydroxy furanones on the onset of cataract in spontaneous cataract rat (ICR/f rat) were tested, and it was observed that HDMF and EHMF inhibited cataract formation. These results suggest that the antioxidative activity of HDMF and EHMF against superoxide radicals in lens tissue contributed to inhibiting the onset of spontaneous cataract.

• 社団法人日本農芸化学会の論文
• 1998-10-23

著者

• Sakai Takafumi

  Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University

• Sakai T

  Kyoto Univ. Kyoto Jpn

• YAMAKOSHI Jun

  Research and Development Division, Kikkoman Corporation

• SAITO Makoto

  Research and Development Division, Kikkoman Corporation

• Mori Kenji

  Department of Biochemistry, National Cardiovascular Center Research Institute

• Sakai T

  Kikkoman Corp. Chiba Jpn

• KASAI Kouichi

  Research and Development Division, Kikkoman Corporation

• Saito Makoto

  Research And Development Division Kikkoman Corporation

• Kasai K

  Research And Development Division Kikkoman Corporation

• Kasai Kouichi

  Research And Development Division Kikkoman Corporation

• Koga Takuro

  Biochemical Division Kikkoman Corporation

• Koga Takuro

  Noda Institute For Scientific Research

• 松浦 克子

  キッコーマン株式会社 研究本部

• SASAKI Tsutomu

  Research and Development Division, Kikkoman Corporation

• MATSUDO Takanao

  Research and Development Division, Kikkoman Corporation

• Matsudo T

  Kikkoman Corp. Chiba Jpn

• Matsudo Takanao

  Research And Development Division Kikkoman Corporation

• Takagi S

  Ehime Prefectural Fisheries Experimental Station

• Koga T

  National Institute Of Advanced Industrial Science And Technology

• Yamakoshi Jun

  Research And Development Division Kikkoman Corporation

• Mori K

  Sci. Univ. Tokyo Tokyo Jpn

• Saito M

  Research And Development Division Kikkoman Corporation

• Yamakoshi J

  Research And Development Division Kikkoman Corporation

• Mori Kenji

  Department Of Biochemistry National Cardiovascular Center Research Institute

• Mori Kenji

  Department Of Agricultural Chemistry The University Of Tokyo

• Mori Kenji

  Department Of Agricultural Chemistry Nagoya University

• Saito Makoto

  Research & Development Division Kikkoman Corporation

• Mori Kenji

  Department Of Agricultural Chemistry College Of Science And Technology The University Of Tokyo

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