Inhibitory Effect of an Ellagic Acid-Rich Pomegranate Extract on Tyrosinase Activity and Ultraviolet-Induced Pigmentation
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概要
- 論文の詳細を見る
A pomegranate extract (PE) from the rind containing 90% ellagic acid was tested for its skin-whitening effect. PE showed inhibitory activity against mushroom tyrosinase in vitro, and the inhibition by the extract was comparable to that of arbutin, which is a known whitening agent. PE, when administered orally, also inhibited UV-induced skin pigmentation on the back of brownish guinea pigs. The intensity of the skin-whitening effect was similar between guinea pigs fed with PE and those fed with L-ascorbic acid. PE reduced the number of DOPA-positive melanocytes in the epidermis of UV-irradiated guinea pigs, but L-ascorbic acid did not. These results suggest that the skin-whitening effect of PE was probably due to inhibition of the proliferation of melanocytes and melanin synthesis by tyrosinase in melanocytes. PE, when taken orally, may be used as an effective whitening agent for the skin.
- 社団法人 日本農芸化学会の論文
- 2005-12-23
著者
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YAMAKOSHI Jun
Research and Development Division, Kikkoman Corporation
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KASAI Kouichi
Research and Development Division, Kikkoman Corporation
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YOSHIMURA Mineka
Research and Development Division, Kikkoman Corporation
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KOGA Takuro
Biochemical Division, Kikkoman Corporation
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Kasai K
Research And Development Division Kikkoman Corporation
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Kasai Kouichi
Research And Development Division Kikkoman Corporation
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Yoshimura Mineka
Research And Development Division Kikkoman Corporation
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Yoshimura Mineka
Research & Development Division Kikkoman Corporation
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Koga Takuro
Biochemical Division Kikkoman Corporation
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Koga T
National Institute Of Advanced Industrial Science And Technology
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Yamakoshi Jun
Research And Development Division Kikkoman Corporation
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WATANABE Yuko
Research and Development Division, Kikkoman Corporation
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Yamakoshi J
Research And Development Division Kikkoman Corporation
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Watanabe Yuko
Research And Development Division Kikkoman Corporation
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