Isolation and Characterization of a Novel Immunomodulating Fraction from Soybeans
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概要
- 論文の詳細を見る
A novel immunomodulating fraction, SP-MAF1, was isolated from soybeans as a polysaccharide-protein complex by hot water extraction followed by acid treatment, ethanol treatment, and chromatography on a DEAE-Sepharose CL-6B column, and was characterized in some biological activities. SP-MAF1 increased glycolysis and IL-1 production by macrophages, but did not affect TNF production. SP-MAF1 also increased splenocyte proliferation that was induced by LPS and ConA, and ConA-induced production of IL-2 by splenocytes. In an in vivo test, the mean survival times of SP-MAF1-treated mice bearing FM3A were significantly longer than those of non-treated group. Since SP-MAF1 affected macrophages and splenocytes but not tumor cell growth, this effect may be mediated by the host immune system. Furthermore SP-MAF1 had a capacity to suppress the TNBS-induced DTH reaction. These results suggested that SP-MAF1 could either enhance or suppress immune functions.
- 社団法人日本農芸化学会の論文
- 1993-03-23
著者
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KIKUCHI Mamoru
Research and Development Division, Kikkoman Corporation
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Koga Takuro
Biochemical Division Kikkoman Corporation
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Koga Takuro
Research And Development Division Kikkoman Corporation
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Kikuchi Masanori
Department Of Food Production And Utility Development Graduate School Of Dairy Science Research Raku
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Koga T
National Institute Of Advanced Industrial Science And Technology
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Kikuchi M
Kikkoman Corp. Chiba Jpn
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Kikuchi Mamoru
Res. And Dev. Div. Kikkoman Corp.
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Kikuchi Mamoru
Research & Development Division Kikkoman Corporation
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Kikuchi M
Res. And Dev. Div. Kikkoman Corp.
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