A New Cytotoxic 2H-Pyran Compound Produced by Acid Treatment of the Fermentation Broth of Streptomyces Sp.
スポンサーリンク
概要
- 論文の詳細を見る
A new cytotoxic substance was isolated following acid treatment of fermented broth of a Streptomyces strain numbered MJ915-WF12. The structure was elucidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration and ring reformation of the precursor material in cultured broth by acid.
- 公益社団法人日本薬学会の論文
- 1999-05-15
著者
-
Iinuma H
Microbial Chemistry Res. Center
-
HAMADA Masa
Institute of Microbial Chemistry
-
TAKEUCHI Tomio
Institute of Microbial Chemistry
-
Kondo S
Institute Of Microbial Chemistry
-
TSUCHIDA Toshio
Institute of Microbial Chemistry
-
IINUMA Hironobu
Institute of Microbial Chemistry
-
Hamada M
Institute Of Microbial Chemistry
-
KUNIMOTO Setsuko
Institute of Microbial Chemistry
-
KUNIMOTO Setsuko
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
-
NOSAKA Chisato
Institute of Microbial Chemistry
-
TAKIZAWA Toshio
Teikyo University Institute of Medical Mycology
-
OHSONO MICHIYO
Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute
-
MASUDA Thoru
the Institute for Chemotherapy, M. V. R. F.
-
OHSONO Michiyo
the Institute for Chemotherapy, M. V. R. F.
-
Masuda Thoru
The Institute For Chemotherapy M. V. R. F.
-
Ohsono Michiyo
Microbial Chemistry Research Center Numazu Bio-medical Research Institute
-
Kunimoto S
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
-
Takeuchi Tomio
Institute For Chemotherapy M.c.r.f.
-
Inoue Hiroyuki
Numazu Bio-medical Research Institute Microbial Chemistry Research Foundation
関連論文
- Futalosine and Its Derivatives, New Nucleoside Analogs
- Synthesis and antimetastatic activity of 6-Trichloracetamido and 6-Guanidino Analogues of Siastatin B
- Synthesis and Activities of Bactobolin Derivatives Having New Functionality at C-3
- Synthesis and Activity of 3-epi-Actinobolin
- Synthesis and Activities of Bactobolin Derivatives Based on the Alteration of the Functionality at C-3 Position
- Synthesis and Protein Tyrosine Phosphatase Inhibitory Activity of Dephostatin Analogs
- Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice
- Sulphostin, a Potent Inhibitor for Dipeptidyl Peptidase IV from Streptomyces sp. MK251-43F3
- Synthesis and Biological Evaluation of Cytogenin Derivatives
- Migrastatin, a Novel 14-Membered Lactone from Streptomyces sp. MK929-43F1
- Inhibition of Angiogenesis by a New Isocoumarin, NM-3
- Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4 II. Structure Determination
- Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4 I. Taxonomy, Fermentation, Isolation, Physico-chemical properties and Biological Activities
- Isolation of a Novel Cyclic Hexadepsipeptide Pipalamycin from Streptomyces as an Apoptosis-inducing Agent
- Morphological Alterations of Saccharomyces cerevisiae Induced by Benanomicin A, an Antifungal Antibiotic with Mannan Affinity
- Mode of Antifungal Action of Benanomicin A in Saccharomyces cerevisiae
- Selective Deoxygenation and O-Methylation of Benanomicin A:Synthesis of 9-Deoxy-, 9-O-Methyl- and 14-O-Methylbenanomicin A
- A Synthetic Approach to Benanomicin A 2. Synthesis of the Substituted 5,6-Dihydrobenzo[a]naphthacenequinone
- A Synthetic Approach to Benanomicin A 1. Synthesis of 5,6-Dihydrobenzo[a]naphthacenequinone
- Structures of Two Remarkable Dimerization Products of Sarkomycin
- Antifungal Antibiotic Benanomicin A Increases Susceptibility of Candida albicans to Phagocytosis by Murine Macrophages
- Binding of Benanomicin A to Fungal Cells in Reference to its Fungicidal Action
- New Bellenamine Homologs Inhibiting Human Immunodeficiency Virus Type 1 Infectivity
- Isolation from Streptomyces of a Novel Naphthoquinone Compound, Naphthablin, That Inhibits Abl Oncogene Functions
- Biosynthesis of Neothramycin
- Inhibitory Effect of Laidlomycin on Human Immunodeficiency Virus Replication
- Eulicin Inhibits Human Immunodeficiency Virus Infection and Replication
- Thiazinotrienomycins, New Ansamycin Group Antibiotics
- HIF-1-Dependent VEGF Reporter Gene Assay by a Stable Transformant of CHO Cells
- Kigamicins, Novel Antitumor Antibiotics I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities
- ICM0201, a New Inhibitor of Osteoclastogenesis from Cunninghamella sp. F-1490 II. Structure Determination and Synthesis
- ICM0201, a New Inhibitor of Osteoclastogenesis from Cunninghamella sp. F-1490 I. Taxonomy, Fermentation, Isolation and Biological Activities
- Inhibition of Proteasome Activity by Tyropeptin A in PC12 Cells(Biochemistry & Molecular Biology)
- Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp. : I. Taxonomy, Isolation and Biological Activities
- Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2 : II. Structure Determination and Synthesis
- Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2 : I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities
- Isolation and Structural Determination of Phepropeptins A, B, C, and D, New Proteasome Inhibitors, Produced by Streptomyces sp.
- Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1 : Taxonomy, Fermentation, Isolation and Biological Activities
- Inhibition of Rat Embryo Histidine Decarboxylase by Epoxyquinomicins
- MK800-62F1, a New Inhibitor of Apoptotic Cell Death, from Streptomyces diastatochromogenes MK800-62F1 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity
- Diperamycin, a New Antimicrobial Antibiotic Produced by Streptomyces griseoaurantiacus MK393-AF2 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
- MJ347-81F4 A & B, Novel Antibiotics from Amycolatopsis sp.: Taxonomic Characteristics, Fermentation, and Antimicrobial Activity
- Cremimycin, a Novel 19-Membered Macrocyclic Lactam Antibiotic, from Streptomyces sp.
- Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis III. Physico-chemical Properties and Structure Determination
- Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis II. Effect on Type II Collagen-induced Arthritis in Mice
- Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis I. Taxonomy, Fermentation, Isolation and Antimicrobial Activities
- Discovery of Methyl-2-(2'-hydroxyphenyl)-2-oxazoline-4-carboxylate as a Secondary Metabolite from Actinomadura sp.
- Heliquinomycin, a New Inhibitor of DNA Helicase, Produced by Streptomyces sp. MJ929-SF2 III. Biosynthesis
- Caprazamycin B, a Novel Anti-tuberculosis Antibiotic, from Streptomyces sp
- Tubelactomicin A, a Novel 16-Membered Lactone Antibiotic, from Nocardia sp. : I. Taxonomy, Production, Isolation and Biological Properties
- Identification of Strain MF861-C4, a Kasugamycin-Producing Actinomycete, as Streptomyces albulus
- Streptomyces kasugaensis sp. nov. : A New Species of Genus Streptomyces
- Thienodolin, a New Plant Growth-regulating Substance Produced by a Streptomycete Strain : I. Taxonomy and Fermentation of the Producing Strain, and the Isolation and Characterization of Thienodolin
- DNA Sequencing and Transcriptional Analysis of the Kasugamycin Biosynthetic Gene Cluster from Streptomyces kasugaensis M338-M1
- Some Biological and Biochemical Activities of Resormycin, a Novel Herbicidal Antibiotic
- Nocardia vinacea sp. nov.
- New Triene-ansamycins, Thiazinotrienomycins F and G and a Diene-ansamycin, Benzoxazomycin
- ABC Transporter Genes, kasKLM, Responsible for Self-resistance of a Kasugamycin Producer Strain
- Anticancer and Some Biological Activities of Thiazinotrienomycin B
- Saccharothrix tangerinus sp. nov., the Producer of the New Antibiotic Formamicin : Taxonomic Studies
- A 7.6kb DNA Region from Streptomyces kasugaensis M338-M1 Includes Some Genes Responsible for Kasugamycin Biosynthesis
- Correlation between the Presence of kac, Kasugamycin Acetyltransferase Gene, and the Productivity of Kasugamycin in Streptomyces
- Hydroxymycotrienins A and B, New Ansamycin Group Antibiotics
- New Strobilurins O and P from a Mushroom
- Melleolides K, L and M, New Melleolides from Armillariella mellea
- Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73-NF4 II. Structure Determination
- Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73-NF4 I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities
- A New Cytotoxic 2H-Pyran Compound Produced by Acid Treatment of the Fermentation Broth of Streptomyces Sp.
- Nothramicin, a New Anthracycline Antibiotic from Nocardia sp. MJ896-43F17
- Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1 II. Structure Determination
- Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1 I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities
- Latctonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis
- Pyralomicins, Novel Antibiotics from Microtetraspora spiralis I. Taxonomy and Production
- Amicenomycins A and B, New Antibiotics from Streptomyces sp.MJ384-46F6
- Azicemicins A and B, New Antimicrobial Agents Produced by Amycolatopsis II.Structure Determination
- Tetrodecamycin and Dihydrotetrodecamycin, New Antimicrobial Antibiotics against Pasteurella piscicida Produced by Streptomyces nashvillensis MJ885-mF8 II.Structure Determination
- Pyralomicins, New Antibiotics from Actinomadura spiralis
- Novel Antibiotics, Amythiamicins IV.A Mutation in the Elongation Factor Tu Gene in a Resistant Mutant of B.subtilis
- Cloning and Nucleotide Sequencing of the Antitumor Antibiotic C-1027 Apoprotein Gene
- kasT Gene of Streptomyces kasugaensis M338-M1 Encodes a DNA-binding Protein which Binds to Intergenic Region of kasU-kasJ in the Kasugamycin Biosynthesis Gene Cluster
- Vinylamycin, a New Depsipeptide Antibiotic, from Streptomyces sp.
- The Long-lasting Antiproliferative Effect of 15-Deoxyspergualin through its Spermidine Moiety
- Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues
- Heliquinomycin, a New Inhibitor of DNA Helicase, Produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities
- Epoxyquinomicins A and B, New Antibiotics from Amycolatopsis
- 4′-Deacetyl-(-)-griseusins A and B, New Naphthoquinone Antibiotics from an Actinomycete
- Amidenin, a New Plant Growth-regulating Substance Isolated from Amycolatopsis sp.
- Epostatin, New Inhibitor of Dipeptidyl Peptidase II, Produced by Streptomyces sp. MJ995-OF5 I. Taxonomy of Producing Strain, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
- Phebestin, a New Inhibitor of Aminopeptidase N, Produced by Streptomyces sp. MJ716-m3
- Resormycin, a Novel Herbicidal and Antifungal Antibiotic Produced by a Strain of Streptomyces platensis I. Taxonomy, Production, Isolation and Biological Properties
- Fromamicin, a Novel Antifungal Antibiotic Produced by a Strain of Saccharothrix sp. I. Taxonomy, Production, Isolation and Biological Properties
- Azicemicins A and B, New Antimicrobial Agent Produced by Amycolatopsis:I.Taxonomy, Fermentation, Isolation, Characterization and Biological Activities
- Isolation of Novel Saquayamycins as Inhibitors of Farnesyl-protein Transferase
- Derivatives of Tetrodecamycin
- Tetrodecamycin and Dihydrotetrodecamycin, New Antimicrobial Antibiotics against Pasteurella piscicida Produced by Streptomyces nashvillensis MJ885-mF8 I.Taxonomy, Fermentation, Isolation, Characterization and Biological Activities
- Rapid characterization by colony direct PCR of distribution specificity in Streptomyces of kan gene encoding a specific aminoglycoside-3-N-acetyltransferase
- Ochracenomicins A, B and C, New Benz [a] anthraquinone Antibiotics from Amicolatopsis sp.
- Paleic acid, a fatty acid from Paenibacillus sp. : taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and-Pasteurella activity
- NBRI17671, a new antitumor compound, produced by Acremonium sp. CR 17671
- NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716