Inhibition of Proteasome Activity by Tyropeptin A in PC12 Cells(Biochemistry & Molecular Biology)

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概要

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• Tyropeptin A, a potent proteasome inhibitor not reported before, was produced by Kitasatospora sp. MK993-dF2. In this study, we investigated the effects of tyropeptin A on proteasome activity in PC12 cells. Tyropeptin A inhibited the intracellular proteasome activity in a dose-dependent way and seemed to cause neurite outgrowth. As expected, ubiquitinated proteins that should be substrates for the proteasome accumulated in cells treated with tyropeptin A. Hence, it appears that tyropeptin A can permeate into cells and there inhibit the intracellular proteasome activity.

• 社団法人日本農芸化学会の論文
• 2002-10-23

著者

• Iinuma H

  Microbial Chemistry Res. Center

• SAWA Ryuichi

  Microbial Chemistry Research Center

• Takeuchi T

  Bioresource Laboratories Mercian Corp.

• Takeuchi T

  Institute Of Microbial Chemistry

• IINUMA Hironobu

  Institute of Microbial Chemistry

• Sawa R

  Microbial Chemistry Research Center

• TAKIZAWA Toshio

  Teikyo University Institute of Medical Mycology

• MOMOSE Isao

  Institute of Microbial Chemistry

• SEKIZAWA Ryuichi

  Institute of Microbial Chemistry

• TAKEUCHI Tomoi

  Institute of Microbial Chemistry

• Takeuchi Toshio

  Research And Development Department Kibun Food Chemifa Co. Ltd.

• Imoto M

  Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University

• Imoto M

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Sekizawa R

  Microbial Chemistry Research Center

• Sawa Ryuichi

  Institute Of Microbial Chemistry

• Takeuchi T

  M.c.r.f. Shizuoka Jpn

• Momose Isao

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Inoue Hiroyuki

  Numazu Bio-medical Research Institute Microbial Chemistry Research Foundation

• Takeuchi T

  Inst. Microbial Chemistry Shinagawa‐ku Jpn

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