Stimulation of Cellular XTT Reduction by Cytochrome Oxidase Inhibitors
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概要
- 論文の詳細を見る
XTT reducing activity by CHO and L1210 cells was found to be stimulated by the presence of cytochrome oxidase inhibitors such as NaN_3 or KCN. Among the other respiratory chain inhibitors, antimycin A (a complex III inhibitor) and chlorpromazine inhibited cellular XTT reduction, and rotenone and malonate showed sligth inhibition and no effect, respectively. It is suggested that XTT reduction is coupled with the respiratory chain via cytochrome c, which is located between complexes III and IV (cytochrome oxidase).
- 公益社団法人日本薬学会の論文
- 1999-06-15
著者
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TAKEUCHI Tomio
Institute of Microbial Chemistry
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Kondo S
Institute Of Microbial Chemistry
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Takeuchi T
Bioresource Laboratories Mercian Corp.
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KUNIMOTO Setsuko
Institute of Microbial Chemistry
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KUNIMOTO Setsuko
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
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NOSAKA Chisato
Institute of Microbial Chemistry
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TAKIZAWA Toshio
Teikyo University Institute of Medical Mycology
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Kunimoto S
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
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Takeuchi Tomio
Institute For Chemotherapy M.c.r.f.
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