Futalosine and Its Derivatives, New Nucleoside Analogs
スポンサーリンク
概要
- 論文の詳細を見る
Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives of futalosine were prepared. 6-O-Methylfutalosine methylester inhibited growth of HeLa-S3 cells in vitro (IC_<50>=19.5μg/ml) in contrast to the weak activity of futalosine. 6-O-Methylfutalosine methylester at concentrations higher than 10μg/ml inhibited incorporation of ^3H-TdR and ^3H-UR but not ^3H-Leu into the acid-soluble fractions of HeLa-S3 cells.
- 1999-07-15
著者
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Nakagawa H
Biochemistry Division National Cancer Center Research Institute
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Nakagawa H
Osaka Univ. Medical School Osaka
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Hori M
Showa Pharmaceutical University
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HOSOKAWA Nobuo
Institute of Microbial Chemistry
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NAGANAWA Hiroshi
Institute of Microbial Chemistry
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KASAHARA Takako
Institute of Microbial Chemistry
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HATTORI Seiko
Institute of Microbial Chemistry
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HAMADA Masa
Institute of Microbial Chemistry
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TAKEUCHI Tomio
Institute of Microbial Chemistry
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YAMAMOTO Shinobu
Showa College of Pharmaceutical Sciences
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TSUCHIYA Kayoko
Showa College of Pharmaceutical Sciences
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HORI Makoto
Showa College of Pharmaceutical Sciences
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Nakagama Hitoshi
国立がんセンター研究所 生化学部
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Yamamoto Shuhei
Department Of Chemistry Graduate School Of Science Osaka City University
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Takeuchi T
Bioresource Laboratories Mercian Corp.
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Takeuchi T
Institute Of Microbial Chemistry
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Hattori S
Microbial Chemistry Research Center
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Hamada M
Institute Of Microbial Chemistry
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Hosokawa Nobuo
Microbial Chemistry Research Center
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山本 晋
Faculty Of Pharmaceutical Sciences Osaka University
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Hori M
Hokkaido Univ. Graduate School Of Pharmaceutical Sci. Sapporo Jpn
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Hosokawa N
Microbial Chemistry Research Center
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TAKIZAWA Toshio
Teikyo University Institute of Medical Mycology
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Tsuchiya Kayoko
Showa Pharmaceutical University
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Takeuchi Toshio
Research And Development Department Kibun Food Chemifa Co. Ltd.
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Tsuchiya K
Showa Pharmaceutical University
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Yamamoto Shozo
Department Of Biochemistry Tokushima University School Of Medicine
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Takeuchi Tomio
Institute For Chemotherapy M.c.r.f.
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Matsumoto Hiroshi
Tokushima Research Center Taiho Pharmaceutical Co. Ltd.
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