Cloning and Nucleotide Sequencing of the Antitumor Antibiotic C-1027 Apoprotein Gene

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概要

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• The apoprotein gene for a chromoprotein antitumor antibiotic, C-1027,was cloned from the producer strain, Streptomyces globisporus C-1027,and sequenced. The process verified that ; (1) the sequence included the entire structural gene directing a precursor of the apoprotein (pre-apoprotein having Met^1-Ala^<33> leader peptide ahead of the apoprotein) and flanking regions, (2) the amino acid sequence of the apoprotein deduced from the base sequence perfectly matched the one based on protein analysis, ^<1)> (3) 3rd letters of codons were 88% G or C, while the 1st plus the 2nd letters were 63% G or C, (4) the structural gene had 57% homology with that of macromomycin apoprotein (mcmA) while the flanking regions had little homology with the corresponding ones of mcmA, except some homology at the -10th and -35th promoter regions, and (5) the gene was transcribed as a monocistronic mRNA in an early growth phase, independent of chromophore production.

• 社団法人日本農芸化学会の論文
• 1992-10-23

著者

• Hori M

  Showa Pharmaceutical University

• HAMADA Masa

  Institute of Microbial Chemistry

• HORI Makoto

  Showa College of Pharmaceutical Sciences

• Hamada M

  Institute Of Microbial Chemistry

• Hori M

  Hokkaido Univ. Graduate School Of Pharmaceutical Sci. Sapporo Jpn

• IKENO Souichi

  Showa College of Pharmaceutical Sciences

• SAKATA Nobuo

  Showa College of Pharmaceutical Sciences

• Otani Toshio

  Biological Research Laboratory Taiho Pharmaceutical Co. Ltd.

• Sakata N

  Showa College Of Pharmaceutical Sciences

• Ikeno S

  Showa Pharmaceutical University

• Otani T

  Tokushima Research Center Taiho Pharmaceutical Co. Ltd.

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