Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues

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概要

• 論文の詳細を見る

• A member of the cyclic hexadepsipeptide family, PD124, 966, isolated from a fermentation product of an actinomycete, inhibited poly(ADP-ribose) glycohydrolase (Parg) with IC50 of 40μg/ml. A novel cyclic peptide, pargamicin, isolated from a fermentation broth of Amicolatopsis sp., also inhibited Parg with IC50 of 28μg/ml. A linear peptide containing piperazic acid residues, piperastatin A, isolated from Streptomyces lavendofoliae, did not inhibit Parg activity.

• 日本学士院の論文

著者

• NAKAGAMA Hitoshi

  Biochemistry Division, National Cancer Center Research Institute

• HAMADA Masa

  Institute of Microbial Chemistry

• TAKEUCHI Tomio

  Institute of Microbial Chemistry

• Nakagama Hitoshi

  Biochemistry Division National Cancer Center Research Institute

• Mori M

  Department Of Oral-maxillofacial Surgery Asahi University School Of Dentistry:medicaraise Corporatio

• SUGIMURA Takashi

  Biochemistry Division, National Cancer Center Research Institute

• NOZAKI Tadashige

  Biochemistry Division, National Cancer Center Research Institute

• MASUTANI Mitsuko

  Biochemistry Division, National Cancer Center Research Institute

• SHIMOKAWA Takashi

  Biochemistry Division, National Cancer Center Research Institute

• Mori M

  Department Of Oral Surgery Gifu College Of Dentistry

• Muto Masahiro

  Radiat. Hazards Res. G. Nirs

• IGARASHI Masayuki

  Institute of Microbial Chemistry

• HORI Makoto

  Institute of Microbial Chemistry

• IGARASHI MASAYUKI

  Microbial Chemistry Research Center

• Masutani Mitsuko

  Biochemistry Division National Cancer Center Research Institute

• Igarashi M

  Yamagata Univ. Yamagata Jpn

• Igarashi M

  Microbial Chemistry Research Center

• Masutani M

  National Cancer Cent. Res. Inst. Tokyo Jpn

• Muto Masahiro

  Department Of Oral Pathology Osaka Dental University

• SHIBATA Atsushi

  Biochemistry Division, National Cancer Center Research Institute

• OAMI Sachiho

  Biochemistry Division, National Cancer Center Research Institute

• Shimokawa Takashi

  Biochemistry Division National Cancer Center Research Institute

• Tamai Susumu

  Cancer Prevention Division National Cancer Center Research Institute

• Takeuchi Tomio

  Institute For Chemotherapy M.c.r.f.

• Sugimura Takashi

  Biochemistry Division National Cancer Center

• Sasaki Toru

  Tokushima Research Center Taiho Pharmaceutical Co. Ltd.

• Mori Masahiko

  Div. Radiobiology And Biodosimetory

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